Cited by 1,650Carcinogens and Genotoxicity AssessmentCancer-related Molecular PathwaysDNA Repair Mechanisms

The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

Abstract

Cigarette smoke carcinogens such as benzo[ a ]pyrene are implicated in the development of lung cancer. The distribution of benzo[ a ]pyrene diol epoxide (BPDE) adducts along exons of the P53 gene in BPDE-treated HeLa cells and bronchial epithelial cells was mapped at nucleotide resolution. Strong and selective adduct formation occurred at guanine positions in codons 157, 248, and 273. These same positions are the major mutational hotspots in human lung cancers. Thus, targeted adduct formation rather than phenotypic selection appears to shape the P53 mutational spectrum in lung cancer. These results provide a direct etiological link between a defined chemical carcinogen and human cancer.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.274.5286.430

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 24 references

1 of the 24 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. Greenblatt M. S., Bennett W. P., Hollstein M., Harris C. C., Cancer Res. 54, 4855 (1994).
  2. Ruggeri B., et al., ibid. 90, 1013 (1993).
  3. Tornaletti S., Pfeifer G. P., Oncogene 10, 1493 (1995).
  4. Puisieux A., Lim S., Groopman J., Ozturk M., Cancer Res. 51, 6185 (1991).
  5. Rideout W. M., Coetzee G. A., Olumi A. F., Jones P. A., ibid. 249, 1288 (1990).

Cited by

Sorted by citations

Items 701–800 of 999

Metadata

Authors
Denissenko, M. F., Pao, A., Tang, M.-S., & Pfeifer, G. P.
Affiliations
  • Beckman Research Institute (US)
  • A. Pao and M.-s. Tang, M. D. Anderson Cancer Center, University of Texas, Science Park, Smithville, TX 78957, USA.
Venue
Science
Published
1996-10-18
Volume
274
Issue
5286
Pages
430-432
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1976056213
Cited by
1,650
References
24
Citations by year
2026: 16 · 2025: 16 · 2024: 17 · 2023: 16 · 2022: 15 · 2021: 26 · 2020: 26 · 2019: 28 · 2018: 29 · 2017: 48 · 2016: 40 · 2015: 45 · 2014: 63 · 2013: 39 · 2012: 69
FWCI
40.80
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r01ca065652-01a1)
  • National Cancer Institute (CA65652)
  • National Institute of Environmental Health Sciences (ES03124, R01ES003124)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords
benzo[a]pyrene, benzo[a]pyrene diol epoxide, DNA adducts, p53, lung cancer, mutational hotspots, tobacco smoke carcinogens, mutation spectrum, HeLa cells, bronchial epithelial cells, guanine adducts
MeSH terms
Bronchi, Carcinogens, Cells, Cultured, Codon, Exons, Fibroblasts, HeLa Cells, Humans, Lung Neoplasms, Mutagens, Mutation, Plants, Toxic, Smoke, Nicotiana, 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide, Dinucleoside Phosphates, Genes, p53, DNA Adducts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review