Cited by 1,650Carcinogens and Genotoxicity AssessmentCancer-related Molecular PathwaysDNA Repair Mechanisms

The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

Denissenko, Mikhail F., Pao, Annie, Tang, Moon-shong, Pfeifer, Gerd P.·1996·Science

Open this paper in CoChat — free account

Abstract

Cigarette smoke carcinogens such as benzo[ a ]pyrene are implicated in the development of lung cancer. The distribution of benzo[ a ]pyrene diol epoxide (BPDE) adducts along exons of the P53 gene in BPDE-treated HeLa cells and bronchial epithelial cells was mapped at nucleotide resolution. Strong and selective adduct formation occurred at guanine positions in codons 157, 248, and 273. These same positions are the major mutational hotspots in human lung cancers. Thus, targeted adduct formation rather than phenotypic selection appears to shape the P53 mutational spectrum in lung cancer. These results provide a direct etiological link between a defined chemical carcinogen and human cancer.

Integrity signals

Registry

Crossref · 10.1126/science.274.5286.430

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
Greenblatt, M. S., Bennett, W. P., Hollstein, M., & Harris, C. C. (1994) · PubMed · Cited by 3,463
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559
Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene
MELLON, I. (1987) · Cell · doi:10.1016/0092-8674(87)90151-6 · Cited by 1,228
Molecular Biology of Mutagens and Carcinogens
Singer, B. C., & Grünberger, D. (1983) · Springer eBooks · doi:10.1007/978-1-4613-3772-0 · Cited by 792
5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes
Rideout, W. M., Coetzee, G. A., Olumi, A. F., & Jones, P. A. (1990) · Science · doi:10.1126/science.1697983 · Cited by 640
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation
Hollstein, M. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.1.141 · Cited by 496
NUCLEOTIDE EXCISION REPAIR
Sancar, A., & Tang, M. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb09233.x · Cited by 262
Self-citation
Technologies for Detection of DNA Damage and Mutations
Pfeifer, G. P. (1996) · Springer eBooks · doi:10.1007/978-1-4899-0301-3 · Cited by 262
Self-citation

Show all 24 references

Research works printed but not linked: 5

Greenblatt M. S., Bennett W. P., Hollstein M., Harris C. C., Cancer Res. 54, 4855 (1994).
Ruggeri B., et al., ibid. 90, 1013 (1993).
Tornaletti S., Pfeifer G. P., Oncogene 10, 1493 (1995).
Puisieux A., Lim S., Groopman J., Ozturk M., Cancer Res. 51, 6185 (1991).
Rideout W. M., Coetzee G. A., Olumi A. F., Jones P. A., ibid. 249, 1288 (1990).

Sorted by citations

Items 201–300 of 999

Tuberculosis and malignancy
Falagas, M. E., Kouranos, V., Athanassa, Z., & Kopterides, P. (2010) · QJM · doi:10.1093/qjmed/hcq068 · Cited by 137
Human papillomavirus in head and neck squamous cell carcinoma: are some head and neck cancers a sexually transmitted disease?
Gillison, M. L., Koch, W. M., & Shah, K. V. (1999) · Current Opinion in Oncology · doi:10.1097/00001622-199905000-00010 · Cited by 138
Airway effects of marijuana, cocaine, and other inhaled illicit agents
Tashkin, D. P. (2001) · Current Opinion in Pulmonary Medicine · doi:10.1097/00063198-200103000-00001 · Cited by 134
The p53 network in lung carcinogenesis
Robles, A. I., Linke, S. P., & Harris, C. C. (2002) · Oncogene · doi:10.1038/sj.onc.1205563 · Cited by 138
Cyclooxygenase-2 expression is up-regulated in transitional cell carcinoma and its preneoplastic lesions in the human urinary bladder.
Shirahama, T. (2000) · PubMed · Cited by 135
Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells
Solhaug, A. (2003) · Carcinogenesis · doi:10.1093/carcin/bgh069 · Cited by 141
Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer
Blackford, A. L., Parmigiani, G., Kensler, T. W., Wolfgang, C. L., Jones, S., Zhang, X., Parsons, D. W., Lin, J., Leary, R. J., Eshleman, J. R., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0015 · Cited by 134
Molecular pathogenesis of lung cancer
Fong, K. M., Sekido, Y., & Minna, J. D. (1999) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(99)70121-2 · Cited by 132
Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool
Luo, J., Yang, Q., Tong, W., Hergenhahn, M., Wang, Z., & Hollstein, M. C. (2001) · Oncogene · doi:10.1038/sj.onc.1204080 · Cited by 135
Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells
Sadiković, B., & Rodenhiser, D. I. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.06.012 · Cited by 135
Synthesis and Characterization of Polycyclic Aromatic Hydrocarbon o-Quinone Depurinating N7-Guanine Adducts
McCoull, K. D., Rindgen, D., Blair, I. A., & Penning, T. M. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980182z · Cited by 132
Mass Spectrometry of Structurally Modified DNA
Tretyakova, N. Y., Villalta, P. W., & Kotapati, S. (2013) · Chemical Reviews · doi:10.1021/cr300391r · Cited by 133
Review on proteomic analyses of benzo[a]pyrene toxicity
Verma, N., Pink, M., Rettenmeier, A. W., & Schmitz‐Spanke, S. (2012) · PROTEOMICS · doi:10.1002/pmic.201100466 · Cited by 131
Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer
Belinsky, S. A. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi020 · Cited by 129
Bioremediation of Marine Oil Spills
Prince, R. C., & Atlas, R. M. (2014) · ASM Press eBooks · doi:10.1128/9781555817596.ch7 · Cited by 130
Molecular Epidemiology: On the Path to Prevention?
Perera, F. P. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.8.602 · Cited by 130
3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence
Arlt, V. M. (2005) · Mutagenesis · doi:10.1093/mutage/gei057 · Cited by 130
Estimation of Excess Cancer Risk on Time-Weighted Lifetime Average Daily Intake of PAHs from Food Ingestion
Yoon, E., Park, K., Lee, H., Yang, J., & Lee, C. (2007) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/10807030701226871 · Cited by 128
Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis
Weng, M.-W., Lee, H., Park, S., Hu, Y., Wang, H.-T., Chen, L., Rom, W. N., Huang, W. C. W., Lepor, H., Wu, X., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804869115 · Cited by 128
Self-citation
p53 and K-ras mutations in lung cancers from former and never-smoking women.
Vähäkangas, K., Bennett, W. P., Castrén, K., Welsh, J. A., Ma, K., Blömeke, B., Alavanja, M. C. R., & Harris, C. C. (2001) · PubMed · Cited by 128
An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study.
Shen, H., Sturgis, E. M., Khan, S. G., Qiao, Y., Shahlavi, T., Eicher, S. A., Xu, Y., Wang, X., Strom, S. S., Spitz, M. R., et al. (2001) · PubMed · Cited by 128
Understanding mutagenesis through delineation of mutational signatures in human cancer
Petljak, M., & Alexandrov, L. B. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw055 · Cited by 110
Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens
Seo, K.-Y., Jelinsky, S. A., & Loechler, E. L. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00047-8 · Cited by 126
A Critical Evaluation of DNA Adducts as Biological Markers for Human Exposure to Polycyclic Aromatic Compounds
Godschalk, R., van Schooten, F., & Bartsch, H. (2003) · BMB Reports · doi:10.5483/bmbrep.2003.36.1.001 · Cited by 131
Glutathione S‐transferase M1 null genotype is associated with a decreased risk of myocardial infarction
Wilson, M. H., Grant, P. J., Hardie, L. J., & Wild, C. P. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.5.791 · Cited by 125
DNA adducts as markers of exposure and risk
Phillips, D. H. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.03.008 · Cited by 125
Recomendaciones sobre el estilo de vida
García, R. C., Guillem, F. C., Seco, E. M., Puente, J. M. G., Ramírez‐Manent, J. I., Arango, J. S. J., Martín-Cantera, C., Muñoz, M. J., & Santiago, A. L. (2016) · Atención Primaria · doi:10.1016/s0212-6567(16)30186-x · Cited by 119
Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck
Cheng, L., Sturgis, E. M., Eicher, S. A., Spitz, M. R., & Wei, Q. (2002) · Cancer · doi:10.1002/cncr.10231 · Cited by 123
Food Mutagens
Goldman, R., & Shields, P. G. (2003) · Journal of Nutrition · doi:10.1093/jn/133.3.965s · Cited by 123
Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy
Koki, A. T., Leahy, K. M., & Masferrer, J. L. (1999) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.8.10.1623 · Cited by 124
Human Papillomavirus in Head and Neck Squamous Cell Carcinomas in Nonsmokers
Fouret, P. J., Monceaux, G., Temam, S., Lacourreye, L., & Guily, J. L. S. (1997) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1997.01900050063008 · Cited by 122
Molecular and cellular adaptation of muscle in response to physical training
Booth, F. W., Tseng, B. S., Flück, M., & Carson, J. A. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0326e.x · Cited by 121
A Specific Spectrum of p53 Mutations in Lung Cancer from Smokers: Review of Mutations Compiled in the IARC p53 Database
Hernandez‐Boussard, T., & Hainaut, P. L. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106385 · Cited by 121
Benzo[a]pyrene decreases global and gene specific DNA methylation during zebrafish development
Fang, X., Thornton, C., Scheffler, B. E., & Willett, K. L. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.02.014 · Cited by 120
An update on immunologic mechanisms in the respiratory mucosa in response to air pollutants
Huff, R. D., Carlsten, C., & Hirota, J. A. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.04.012 · Cited by 126
Reactive Oxygen Species Generated by PAH o-Quinones Cause Change-In-Function Mutations in p53
Yu, D., Berlin, J. A., Penning, T. M., & Field, J. M. (2002) · Chemical Research in Toxicology · doi:10.1021/tx010177m · Cited by 120
Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones Produced by the Aldo-Keto-Reductases (AKRs) Generate Abasic Sites, Oxidized Pyrimidines, and 8-Oxo-dGuo via Reactive Oxygen Species
Park, J., Troxel, A. B., Harvey, R. G., & Penning, T. M. (2006) · Chemical Research in Toxicology · doi:10.1021/tx0600245 · Cited by 120
4-Aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene
Feng, Z. (2002) · Carcinogenesis · doi:10.1093/carcin/23.10.1721 · Cited by 120
Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans
van Bokhoven, H., & McKeon, F. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02260-2 · Cited by 122
Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns
Lea, I. A., Jackson, M. A., Li, X., Bailey, S., Peddada, S. D., & Dunnick, J. K. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm176 · Cited by 119
Preferential DNA Damage and Poor Repair Determine ras Gene Mutational Hotspot in Human Cancer
Feng, Z. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.20.1527 · Cited by 115
Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking.
Anttila, S. L., Hakkola, J., Tuominen, P., Elovaara, E., Husgafvel‐Pursiainen, K., Karjalainen, A., Hirvonen, A., & Nurminen, T. (2003) · PubMed · Cited by 118
The Effects of Quercetin on Antioxidant Status and Tumor Markers in the Lung and Serum of Mice Treated with Benzo(a)pyrene
Kamaraj, S., Vinodhkumar, R., Anandakumar, P., Sundaram, J., Ramakrishnan, G., & Devaki, T. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.2268 · Cited by 118
Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans -dihydrodiol activation in human lung A549 cells
Park, J., Mangal, D., Tacka, K. A., Quinn, A. M., Harvey, R. G., Blair, I. A., & Penning, T. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802776105 · Cited by 121
Environmental factors as regulators and effectors of multistep carcinogenesis
Minamoto, T., Mai, M., & Ronai, Z. A. (1999) · Carcinogenesis · doi:10.1093/carcin/20.4.519 · Cited by 120
The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope
Theobald, M., Ruppert, T., Kuckelkorn, U., Hernández, J., Häußler, A., Ferreira, E. A., Liewer, U., Biggs, J., Levine, A. J., Huber, C., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.6.1017 · Cited by 117
Prognostic value ofTP53,KRASandEGFRmutations in nonsmall cell lung cancer: the EUELC cohort
Scoccianti, C., Vesin, A., Martel, G., Olivier, M., Brambilla, E. M., Timsit, J., Tavecchio, L., Brambilla, C., Field, J. K., & Hainaut, P. L. (2012) · European Respiratory Journal · doi:10.1183/09031936.00097311 · Cited by 116
Chemically Reactive Intermediates and Pulmonary Xenobiotic Toxicity
Gram, T. E. (1997) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01336-x · Cited by 116
Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses
Henkler, F., Stolpmann, K., & Luch, A. (2012) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-7643-8340-4_5 · Cited by 119
Chemicals and Drugs Forming Reactive Quinone and Quinone Imine Metabolites
Klopčič, I., & Dolenc, M. S. (2018) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00213 · Cited by 112
Mutant KRAS in aberrant crypt foci (ACF): Initiation of colorectal cancer?
Pretlow, T. P., & Pretlow, T. G. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.06.002 · Cited by 111
Initial Steps of Aromatic Ring Formation in a Laminar Premixed Fuel-Rich Cyclopentene Flame†
Hansen, N., Kasper, T., Klippenstein, S. J., Westmoreland, P. R., Law, M. E., Taatjes, C. A., Kohse‐Höinghaus, K., Wang, J., & Cool, T. A. (2007) · The Journal of Physical Chemistry A · doi:10.1021/jp0683317 · Cited by 111
Use of moss (Tortula muralis Hedw.) for monitoring organic and inorganic air pollution in urban and rural sites in Northern Italy
Gerdol, R., Bragazza, L., Marchesini, R., Medici, A., Pedrini, P., Benedetti, S., Bovolenta, A., & Coppi, S. (2002) · Atmospheric Environment · doi:10.1016/s1352-2310(02)00298-4 · Cited by 111
Effect of smoking cessation on oxidative DNA modification estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion.
Priemé, H., Loft, S., Klarlund, M., Grønbæk, K., Tønnesen, P., & Poulsen, H. E. (1998) · Carcinogenesis · doi:10.1093/carcin/19.2.347 · Cited by 117
Is There a Genetic Basis for Lung Cancer Susceptibility?
Amos, C. I., Xu, W., & Spitz, M. R. (1999) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-59945-3_1 · Cited by 111
Experimental and computational studies of oxidizer and fuel side addition of ethanol to opposed flow air/ethylene flames
McNesby, K. L., Miziolek, A. W., Nguyen, T., DeLucia, F. C., Skaggs, R. R., & Litzinger, T. (2005) · Combustion and Flame · doi:10.1016/j.combustflame.2005.04.003 · Cited by 110
Analysis of 8-oxo-7,8-dihydro-2′-deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms
Marczyński, B., Rihs, H., Roßbach, B., Hölzer, J., Angerer, J., Scherenberg, M., Hoffmann, G. R., Brüning, T., & Wilhelm, M. (2002) · Carcinogenesis · doi:10.1093/carcin/23.2.273 · Cited by 109
Endocrine disruption of the epigenome: a breast cancer link
Knower, K. C., To, S. Q., Leung, Y., Ho, S., & Clyne, C. D. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0513 · Cited by 109
Tumor Protein p53 (TP53) Testing and Li-Fraumeni Syndrome
Sorrell, A., Espenschied, C. R., Culver, J. O., & Weitzel, J. N. (2013) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0020-0 · Cited by 109
Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case–control study
Blankenburg, S., König, I. R., Mößner, R., Laspe, P., Thoms, K., Krüger, U., Khan, S. G., Westphal, G., Berking, C., Volkenandt, M., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi055 · Cited by 109
p53 mutations and exposure to environmental tobacco smoke in a multicenter study on lung cancer.
Husgafvel‐Pursiainen, K., Boffetta, P., Kannio, A., Nyberg, F., Pershagen, G., Mukeria, A., Constantinescu, V., Fortes, C., & Benhamou, S. (2000) · PubMed · Cited by 108
Folate status, metabolic genotype, and biomarkers of genotoxicity in healthy subjects
Zijno, A. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg064 · Cited by 108
Benzo[a]pyrene Induces the Transcription of Cyclooxygenase-2 in Vascular Smooth Muscle Cells
Yan, Z., Subbaramaiah, K., Camilli, T. C., Zhang, F., Tanabe, T., McCaffrey, T. A., Dannenberg, A. J., & Weksler, B. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4949 · Cited by 108
Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study
Perera, F. P. (2002) · Carcinogenesis · doi:10.1093/carcin/23.10.1641 · Cited by 107
Early detection of lung cancer: role of biomarkers
Brambilla, C., Fievet, F., Jeanmart, M., de Fraipont, F., Lantuéjoul, S., Frappat, V., Ferretti, G., Brichon, P. Y., & Moro‐Sibilot, D. (2003) · European Respiratory Journal · doi:10.1183/09031936.02.00062002 · Cited by 105
Medical journals and the shaping of medical knowledge*
Vandenbroucke, J. P. (1998) · The Lancet · doi:10.1016/s0140-6736(98)10208-8 · Cited by 106
Tobacco abstinence symptom suppression: the role played by the smoking‐related stimuli that are delivered by denicotinized cigarettes
Buchhalter, A. R., Acosta, M. C., Evans, S. E., Breland, A. B., & Eissenberg, T. (2005) · Addiction · doi:10.1111/j.1360-0443.2005.01030.x · Cited by 105
Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism
Wohak, L. E., Krais, A. M., Kucab, J. E., Stertmann, J., Øvrebø, S., Seidel, A., Phillips, D. H., & Arlt, V. M. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1409-1 · Cited by 106
Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond
Yasin, B., El‐Fawal, H. A. N., & Mousa, S. A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226210 · Cited by 109
Polycyclic aromatic hydrocarbons: correlations between DNA adducts and ras oncogene mutations
Ross, J. A., & Nesnow, S. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00016-0 · Cited by 105
Differences in aromatic-DNA adduct levels between alveolar macrophages and subpopulations of white blood cells from smokers
Godschalk, R. (1998) · Carcinogenesis · doi:10.1093/carcin/19.5.819 · Cited by 105
Nicotine Induces Resistance to Chemotherapy by Modulating Mitochondrial Signaling in Lung Cancer
Zhang, J., Kamdar, O. J., Le, W., Rosen, G., & Upadhyay, D. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0277oc · Cited by 105
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene.
Heidel, S. M., MacWilliams, P. S., Baird, W. M., Dashwood, W. M., Buters, J., Gonzalez, F. J., Larsen, M. C., Czuprynski, C. J., & Jefcoate, C. R. E. (2000) · PubMed · Cited by 105
Sequence variations in the DNA repair gene XPD and risk of lung cancer in a Chinese population
Liang, G., Xing, D., Miao, X., Tan, W., Yu, C.-Y., Lu, W., & Lin, D. (2003) · International Journal of Cancer · doi:10.1002/ijc.11136 · Cited by 105
Human lung cancer and p53 : The interplay between mutagenesis and selection
Rodin, S. N., & Rodin, A. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180320897 · Cited by 106
Electrochemiluminescent Arrays for Cytochrome P450-Activated Genotoxicity Screening. DNA Damage from Benzo[a]pyrene Metabolites
Hvastkovs, E. G., So, M., Krishnan, S., Bajrami, B., Tarun, M., Jansson, I., Schenkman, J. B., & Rusling, J. F. (2007) · Analytical Chemistry · doi:10.1021/ac061975q · Cited by 104
Detailed Kinetic Study of the Growth of Small Polycyclic Aromatic Hydrocarbons. 1. 1-Naphthyl + Ethyne
Richter, H., Mazyar, O. A., Sumathi, R., Green, W. H., Howard, J. B., & Bozzelli, J. W. (2000) · The Journal of Physical Chemistry A · doi:10.1021/jp002428q · Cited by 104
Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol
Oikawa, S. (2001) · Carcinogenesis · doi:10.1093/carcin/22.8.1239 · Cited by 105
Bulky DNA adducts and risk of cancer: a meta-analysis.
Veglia, F., Matullo, G., & Vineis, P. (2003) · PubMed · Cited by 103
Significance of TP53 mutations in human cancer: A critical analysis of mutations at CpG dinucleotides
Soussi, T., & Béroud, C. (2003) · Human Mutation · doi:10.1002/humu.10189 · Cited by 103
O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.
Wolf, P., Hu, Y. C., Doffek, K. M., Sidransky, D., & Ahrendt, S. A. (2001) · PubMed · Cited by 103
Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors
You, Y.-H. (2000) · Carcinogenesis · doi:10.1093/carcin/21.11.2113 · Cited by 103
Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking
Godschalk, R. (2002) · Carcinogenesis · doi:10.1093/carcin/23.12.2081 · Cited by 102
Vehicle fleet emissions of black carbon, polycyclic aromatic hydrocarbons, and other pollutants measured by a mobile laboratory in Mexico City
Jiang, M., Marr, L. C., Dunlea, E. J., Herndon, S. C., Jayne, J. T., Kolb, C. E., Knighton, W. B., Rogers, T. M., Zavala, M., Molina, L. T., et al. (2005) · Atmospheric chemistry and physics · doi:10.5194/acp-5-3377-2005 · Cited by 102
Formation and Repair of Tobacco Carcinogen‐Derived Bulky DNA Adducts
Hang, B. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/709521 · Cited by 110
L1 retrotransposons, cancer stem cells and oncogenesis
Carreira, P. E., Richardson, S. R., & Faulkner, G. J. (2013) · FEBS Journal · doi:10.1111/febs.12601 · Cited by 100
Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo[a]pyrene
Li, W., Hu, J., Adebalı, O., Adar, S., Yang, Y., Chiou, Y., & Sancar, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706021114 · Cited by 102
Expression of xenobiotic-metabolizing CYPs in human pulmonary tissue
Raunio, H., Hakkola, J., Hukkanen, J., Lassila, A., Päivärinta, K., Pelkonen, O., Anttila, S. L., Piipari, R., Boobis, A. R., & Edwards, R. J. (1999) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(99)80031-1 · Cited by 101
Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice
Selvendiran, K., Banu, S. M., & Sakthisekaran, D. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.07.004 · Cited by 99
Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1
Roos, P. H., & Bolt, H. M. (2005) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.1.2.187 · Cited by 99
Explaining Disease: Correlations, Causes, and Mechanisms
Thagard, P. R. (1998) · Minds and Machines · doi:10.1023/a:1008286314688 · Cited by 99
Interactions of Carcinogen-Bound DNA with Individual DNA Polymerases
Guengerich, F. P. (2006) · Chemical Reviews · doi:10.1021/cr0404693 · Cited by 99
Benzene precursors and formation routes in a stoichiometric cyclohexane flame
Law, M. E., Westmoreland, P. R., Cool, T. A., Wang, J., Hansen, N., Taatjes, C. A., & Kasper, T. (2006) · Proceedings of the Combustion Institute · doi:10.1016/j.proci.2006.07.259 · Cited by 98
AHR- and DNA-Damage-Mediated Gene Expression Responses Induced by Benzo(a)pyrene in Human Cell Lines
Hockley, S. L., Arlt, V. M., Brewer, D. S., Poele, R. T., Workman, P., Giddings, I., & Phillips, D. H. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700252n · Cited by 106
Factors influencing inhibition of eight polycyclic aromatic hydrocarbons in heated meat model system
Min, S., Patra, J. K., & Shin, H. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.07.020 · Cited by 97
In defense of the somatic mutation theory of cancer
Vaux, D. L. (2011) · BioEssays · doi:10.1002/bies.201100022 · Cited by 95
The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma
Ma, K., Cao, B., & Guo, M. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0210-9 · Cited by 96
DNA damage, DNA repair and carcinogenicity: Tobacco smoke versus electronic cigarette aerosol
Tang, M., Lee, H., Weng, M.-W., Wang, H., Hu, Y., Chen, L., Park, S., Chan, H.-W., Xu, J., Wu, X., et al. (2021) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2021.108409 · Cited by 107
Self-citation
Induction and Regulation of the Carcinogen-Metabolizing Enzyme CYP1A1 by Marijuana Smoke and Δ9-Tetrahydrocannabinol
Roth, M. D., Marques-Magallanes, J. A., Yuan, M., Sun, W., Tashkin, D. P., & Hankinson, O. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.3.4252 · Cited by 95
Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo
Tu, Y., Dammann, R., & Pfeifer, G. P. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2176 · Cited by 95
Self-citation

Authors: Denissenko, M. F., Pao, A., Tang, M.-S., & Pfeifer, G. P.
Affiliations: Beckman Research Institute (US)
A. Pao and M.-s. Tang, M. D. Anderson Cancer Center, University of Texas, Science Park, Smithville, TX 78957, USA.
ORCID: Tang, Moon-shong
Pfeifer, Gerd P.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-10-18
Volume: 274
Issue: 5286
Pages: 430-432
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.274.5286.430
OpenAlex: W1976056213
Cited by: 1,650
References: 24
Citations by year: 2026: 16 · 2025: 16 · 2024: 17 · 2023: 16 · 2022: 15 · 2021: 26 · 2020: 26 · 2019: 28 · 2018: 29 · 2017: 48 · 2016: 40 · 2015: 45 · 2014: 63 · 2013: 39 · 2012: 69
FWCI: 40.80
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01ca065652-01a1)
National Cancer Institute (CA65652)
National Institute of Environmental Health Sciences (ES03124, R01ES003124)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: benzo[a]pyrene, benzo[a]pyrene diol epoxide, DNA adducts, p53, lung cancer, mutational hotspots, tobacco smoke carcinogens, mutation spectrum, HeLa cells, bronchial epithelial cells, guanine adducts
MeSH terms: Bronchi, Carcinogens, Cells, Cultured, Codon, Exons, Fibroblasts, HeLa Cells, Humans, Lung Neoplasms, Mutagens, Mutation, Plants, Toxic, Smoke, Nicotiana, 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide, Dinucleoside Phosphates, Genes, p53, DNA Adducts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks