The DOI matches its Crossref record.
Identification of Subunits of the Anaphase-Promoting Complex of Saccharomyces cerevisiae
Abstract
Entry into anaphase and proteolysis of B-type cyclins depend on a complex containing the tetratricopeptide repeat proteins Cdc16p, Cdc23p, and Cdc27p. This particle, called the anaphase-promoting complex (APC) or cyclosome, functions as a cell cycle-regulated ubiquitin-protein ligase. Two additional subunits of the budding yeast APC were identified: The largest subunit, encoded by the APC1 gene, is conserved between fungi and vertebrates and shows similarity to BIMEp from Aspergillus nidulans . A small heat-inducible subunit is encoded by the CDC26 gene. The yeast APC is a 36 S particle that contains at least seven different proteins.
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Citations
Cited by
Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840
The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists
Alberts, B. (1998) · Cell · doi:10.1016/s0092-8674(00)80922-8 · Cited by 1,411
The anaphase promoting complex/cyclosome: a machine designed to destroy
Peters, J.-M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1988 · Cited by 1,315
How Proteolysis Drives the Cell Cycle
King, R. W., Deshaies, R. J., Peters, J.-M., & Kirschner, M. W. (1996) · Science · doi:10.1126/science.274.5293.1652 · Cited by 1,273
Chou, H., Glory, A., & Bachewich, C. (2011) · Eukaryotic Cell · doi:10.1128/ec.00263-10 · Cited by 20
Ütkür, K., Mayer, K., Liu, S., Brinkmann, U., & Schaffrath, R. (2024) · Biomolecules · doi:10.3390/biom14040470 · Cited by 1
Metadata
- Authors
- Zachariae, W., Shin, T. H., Galova, M., Obermaier, B., & Nasmyth, K.
- Venue
- Science
- Published
- 1996-11-15
- Volume
- 274
- Issue
- 5290
- Pages
- 1201-1204
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982515699
- Cited by
- 256
- References
- 0
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- closed
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