The DOI matches its Crossref record.
Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library
Abstract
A solid phase carbohydrate library was synthesized and screened against Bauhinia purpurea lectin. The library, which contains approximately 1300 di- and trisaccharides, was synthesized with chemical encoding on TentaGel resin so that each bead contained a single carbohydrate. Two ligands that bind more tightly to the lectin than Gal-β-1,3-GalNAc (the known ligand) have been identified. The strategy outlined can be used to identify carbohydrate-based ligands for any receptor; however, because the derivatized beads mimic the polyvalent presentation of cell surface carbohydrates, the screen may prove especially valuable for discovering new compounds that bind to proteins participating in cell adhesion.
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Citations
Cited by
Fukui, S., Feizi, T., Galustian, C., Lawson, A. M., & Chai, W. (2002) · Nature Biotechnology · doi:10.1038/nbt735 · Cited by 580
Pulsed Ultrafiltration Mass Spectrometry: A New Method for Screening Combinatorial Libraries
van Breemen, R. B., Huang, C.-R., Nikolic, D., Woodbury, C. P., Zhao, Y.-Z., & Venton, D. L. (1997) · Analytical Chemistry · doi:10.1021/ac970132j · Cited by 167
Metadata
- Authors
- Liang, R., Yan, L., Loebach, J., Ge, M., Uozumi, Y., Sekanina, K., Horan, N., Gildersleeve, J., Thompson, C., Smith, A., Biswas, K., Still, W. C., & Kahne, D.
- Venue
- Science
- Published
- 1996-11-29
- Volume
- 274
- Issue
- 5292
- Pages
- 1520-1522
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057446176
- Cited by
- 277
- References
- 0
- FWCI
- 25.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liang, R., Yan, L., Loebach, J., Ge, M., Uozumi, Y., Sekanina, K., Horan, N., Gildersleeve, J., Thompson, C., Smith, A., Biswas, K., Still, W. C., & Kahne, D. (1996). Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library. Science. https://doi.org/10.1126/science.274.5292.1520
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
