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Association of Src Tyrosine Kinase with a Human Potassium Channel Mediated by SH3 Domain
Abstract
The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains. Direct association of the Src tyrosine kinase with cloned hKv1.5 and native hKv1.5 in human myocardium was observed. This interaction was mediated by the proline-rich motif of hKv1.5 and the SH3 domain of Src. Furthermore, hKv1.5 was tyrosine phosphorylated, and the channel current was suppressed, in cells coexpressing v-Src. These results provide direct biochemical evidence for a signaling complex composed of a potassium channel and a protein tyrosine kinase.
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Cites
Modular binding domains in signal transduction proteins
Cohen, G. B., Ren, R., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90406-9 · Cited by 951
Self-citationRosenmund, C., Carr, D. W., Bergeson, S. E., Nilaver, G., Scott, J. D., & Westbrook, G. L. (1994) · Nature · doi:10.1038/368853a0 · Cited by 371
Cited by
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Pharmacology of cardiac potassium channels
Tamargo, J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.026 · Cited by 466
Electrical Silencing of Drosophila Pacemaker Neurons Stops the Free-Running Circadian Clock
Nitabach, M. N., Blau, J., & Holmes, T. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00737-7 · Cited by 451
Self-citationSupramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels
Dai, S., Hall, D. D., & Hell, J. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00029.2007 · Cited by 332
The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn
Hayashi, T., Umemori, H., Mishina, M., & Yamamoto, T. (1999) · Nature · doi:10.1038/16269 · Cited by 269
Metadata
- Authors
- Holmes, T. C., Fadool, D. A., Ren, R., & Levitan, I. B.
- Venue
- Science
- Published
- 1996-12-20
- Volume
- 274
- Issue
- 5295
- Pages
- 2089-2091
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964285407
- Cited by
- 265
- References
- 2
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Holmes, T. C., Fadool, D. A., Ren, R., & Levitan, I. B. (1996). Association of Src Tyrosine Kinase with a Human Potassium Channel Mediated by SH3 Domain. Science. https://doi.org/10.1126/science.274.5295.2089
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
