The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ
Abstract
Adipocyte differentiation is an important component of obesity and other metabolic diseases. This process is strongly inhibited by many mitogens and oncogenes. Several growth factors that inhibit fat cell differentiation caused mitogen-activated protein (MAP) kinase-mediated phosphorylation of the dominant adipogenic transcription factor peroxisome proliferator-activated receptor γ (PPARγ) and reduction of its transcriptional activity. Expression of PPARγ with a nonphosphorylatable mutation at this site (serine-112) yielded cells with increased sensitivity to ligand-induced adipogenesis and resistance to inhibition of differentiation by mitogens. These results indicate that covalent modification of PPARγ by serum and growth factors is a major regulator of the balance between cell growth and differentiation in the adipose cell lineage.
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Metadata
- Authors
- Hu, E., Kim, J. B., Sarraf, P., & Spiegelman, B. M.
- Venue
- Science
- Published
- 1996-12-20
- Volume
- 274
- Issue
- 5295
- Pages
- 2100-2103
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995398218
- Cited by
- 1,050
- References
- 40
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hu, E., Kim, J. B., Sarraf, P., & Spiegelman, B. M. (1996). Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ. Science. https://doi.org/10.1126/science.274.5295.2100
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
