The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Akt Signaling--Linking Membrane Events to Life and Death Decisions
Abstract
Many growth factors exert their effects on cells by simulating intracellular kinases, which add phosphate groups to proteins. Two reports on p. 661 and p. 665 of this week's issue implicate the oncogenic kinase Akt in IGF-1-mediated neuronal survival (Dudek et al .) and show how lipids can regulate the activity of Akt (Franke et al .). In his Perspective, Hemmings discusses these results and several other recent reports about Akt and its unique mode of activation by phospholipids.
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Citations
Cites
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Self-citation
Cited by
Mayo, L. D., & Donner, D. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181181198 · Cited by 1,230
Role of Translocation in the Activation and Function of Protein Kinase B
Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J. C., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., & Hemmings, B. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31515 · Cited by 1,051
Self-citationAKT plays a central role in tumorigenesis
Testa, J. R., & Bellacosa, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211430998 · Cited by 944
Garofalo, R. S., Orena, S. J., Rafidi, K., Torchia, A. J., Stock, J. L., Hildebrandt, A. L., Coskran, T., Black, S. C., Brees, D. J., Wicks, J. R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16885 · Cited by 726
Heiden, M. G. V., Chandel, N. S., Schumacker, P. T., & Thompson, C. B. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80307-x · Cited by 505
Metadata
- Authors
- Hemmings, B. A.
- Venue
- Science
- Published
- 1997-01-31
- Volume
- 275
- Issue
- 5300
- Pages
- 628-630
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008987764
- Cited by
- 510
- References
- 1
- FWCI
- 17.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
