AKT plays a central role in tumorigenesis

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591 · see citing works

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,612 · see citing works

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

Cantley, L. C., & Neel, B. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4240 · Cited by 2,007 · see citing works

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,837 · see citing works

PI3K: Downstream AKTion Blocks Apoptosis

Franke, T. F., Kaplan, D. R., & Cantley, L. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81883-8 · Cited by 1,692 · see citing works

Mechanisms and consequences of activation of protein kinase B/Akt

Downward, J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80149-x · Cited by 1,304 · see citing works

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

Mayo, L. D., & Donner, D. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181181198 · Cited by 1,230 · see citing works

The Multiple Roles of PTEN in Tumor Suppression

Di Cristofano, A., & Pandolfi, P. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80674-1 · Cited by 1,182 · see citing works

PIK3CA is implicated as an oncogene in ovarian cancer

Shayesteh, L., Lu, Y., Kuo, W.-L., Baldocchi, R. A., Godfrey, T. E., Collins, C. C., Pinkel, D., Powell, B., Mills, G. B., & Gray, J. W. (1999) · Nature Genetics · doi:10.1038/5042 · Cited by 1,158 · see citing works

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

Zhou, B. P., Liao, Y., Xia, W., Spohn, B., Lee, M., & Hung, M. (2001) · Nature Cell Biology · doi:10.1038/35060032 · Cited by 1,135 · see citing works

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

Coffer, P. J., Jin, J., & Woodgett, J. R. (1998) · Biochemical Journal · doi:10.1042/bj3350001 · Cited by 1,067 · see citing works

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

Chan, T. O., Rittenhouse-Simmons, S., & Tsichlis, P. N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.965 · Cited by 981 · see citing works

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

Bellacosa, A., Testa, J. R., Staal, S. P., & Tsichlis, P. N. (1991) · Science · doi:10.1126/science.1833819 · Cited by 939 · see citing works

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

Kandel, E., & Hay, N. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4690 · Cited by 867 · see citing works

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

Bellacosa, A., de Feo, D., Godwin, A. K., Bell, D. W., Cheng, J. Q., Altomare, D. A., Wan, M., Dubeau, L., Scambia, G., Masciullo, V., et al. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910640412 · Cited by 837 · see citing works

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

Cheng, J. Q., Ruggeri, B., Klein, W. M., Sonoda, G., Altomare, D. A., Watson, D. K., & Testa, J. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3636 · Cited by 793 · see citing works

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

Staal, S. P. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.14.5034 · Cited by 772 · see citing works

Mechanism of activation and function of protein kinase B

Alessi, D. R., & Cohen, P. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80062-2 · Cited by 743 · see citing works

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

Cheng, J. Q., Godwin, A. K., Bellacosa, A., Taguchi, T., Franke, T. F., Hamilton, T. C., Tsichlis, P. N., & Testa, J. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9267 · Cited by 737 · see citing works

The mRNA 5′ cap-binding protein eIF4E and control of cell growth

Sonenberg, N., & Gingras, A. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80150-6 · Cited by 673 · see citing works

The ARF/p53 pathway.

Sherr, C. J., & Weber, J. D. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00038-6 · Cited by 654 · see citing works

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway

Skorski, T., Bellacosa, A., Nieborowska‐Skorska, M., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6151 · Cited by 567 · see citing works

Akt activation by growth factors is a multiple-step process: the role of the PH domain

Bellacosa, A., Chan, T. O., Ahmed, N. N., Datta, K., Malstrom, S. E., Stokoe, D., McCormick, F. P., Feng, J., & Tsichlis, P. N. (1998) · Oncogene · doi:10.1038/sj.onc.1201947 · Cited by 548 · see citing works

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

Jones, P. F., Jakubowicz, T., Pitossi, F. J., Maurer, F., & Hemmings, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4171 · Cited by 532 · see citing works

Akt Signaling--Linking Membrane Events to Life and Death Decisions

Hemmings, B. A. (1997) · Science · doi:10.1126/science.275.5300.628 · Cited by 517 · see citing works

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

Muise‐Helmericks, R. C., Grimes, H. L., Bellacosa, A., Malstrom, S. E., Tsichlis, P. N., & Rosen, N. X. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29864 · Cited by 511 · see citing works

Molecular cloning and characterisation of a novel putative protein‐serine kinase related to the cAMP‐dependent and protein kinase C families

Coffer, P. J., & Woodgett, J. R. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16305.x · Cited by 493 · see citing works

Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit

Kang, S. S., Kwon, T., Kwon, D. Y., & Do, S.-I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13085 · Cited by 480 · see citing works

Pleckstrin domain homology

Haslam, R. J., Koide, H., & Hemmings, B. A. (1993) · Nature · doi:10.1038/363309b0 · Cited by 480 · see citing works

Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines

Nakatani, K., Thompson, D. A., Barthel, A., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21528 · Cited by 476 · see citing works

AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells

Sun, M., Wang, G., Paciga, J. E., Feldman, R. I., Yuan, Z., Xiaoling, M., Shelley, S. A., Jove, R., Tsichlis, P. N., Nicosia, S. V., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61714-2 · Cited by 454 · see citing works

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

Chang, H. W., Aoki, M., Fruman, D. A., Auger, K. R., Bellacosa, A., Tsichlis, P. N., Cantley, L. C., Roberts, T. M., & Vogt, P. K. (1997) · Science · doi:10.1126/science.276.5320.1848 · Cited by 412 · see citing works

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

Yuan, Z. Q., Sun, M., Feldman, R. I., Wang, G., Xiaoling, M., Jiang, C. C., Coppola, D., Nicosia, S. V., & Cheng, J. Q. (2000) · Oncogene · doi:10.1038/sj.onc.1203598 · Cited by 385 · see citing works

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

Bellacosa, A., Testa, Staal, S., et al. (1991) · Science · doi:10.1126/science.254.5029.274 · Cited by 365 · see citing works

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling

Kops, G. J. P. L., & Burgering, B. M. T. (1999) · Journal of Molecular Medicine · doi:10.1007/s001099900050 · Cited by 286 · see citing works

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma.

Staal, S. P., Hartley, J. W., & Rowe, W. P. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.7.3065 · Cited by 282 · see citing works

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

Collado, M., Medema, R. H., Garcı́a-Cao, I., Dubuisson, M., Barradas, M., Glassford, J., Rivas, C., Burgering, B. M. T., Serrano, M., & Lam, E. W. ‐. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000759200 · Cited by 268 · see citing works

AKT activation up-regulates insulin-like growth factor-I receptor expression and promotes invasiveness of human pancreatic cancer cells

Tanno, S., Testa, J. R., & KOHGO, Y. (2001) · Gastroenterology · doi:10.1016/s0016-5085(01)80193-1 · Cited by 230 · see citing works

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

Mitsuuchi, Y., Johnson, S. W., Sonoda, G., Tanno, S., Golemis, E. A., & Testa, J. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203080 · Cited by 202 · see citing works

The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential.

Ahmed, N. N., Franke, T. F., Bellacosa, A., Datta, K., Gonzalez-Portal, M. E., Taguchi, T., Testa, J. R., & Tsichlis, P. N. (1993) · PubMed · Cited by 160 · see citing works

Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis

Cheng, J. Q., Altomare, D. A., Klein, M. A., Lee, W.-C., Kruh, G. D., Lissy, N. A., & Testa, J. R. (1997) · Oncogene · doi:10.1038/sj.onc.1201121 · Cited by 148 · see citing works

Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells

Thant, A. A., Nawa, A., Kikkawa, F., Ichigotani, Y., Zhang, Y., Sein, T. T., Amin, A. R. M. R., & Hamaguchi, M. (2000) · Clinical & Experimental Metastasis · doi:10.1023/a:1010921730952 · Cited by 146 · see citing works

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

Altomare, D. A., Lyons, G. E., Mitsuuchi, Y., Cheng, J. Q., & Testa, J. R. (1998) · Oncogene · doi:10.1038/sj.onc.1201750 · Cited by 138 · see citing works

PDK2: A Complex Tail in One Akt

Chan, T. O., & Tsichlis, P. N. (2001) · Science s STKE · doi:10.1126/stke.2001.66.pe1 · Cited by 133 · see citing works

Oncogenic transformation induced by membrane-targeted Akt2 and Akt3

Mende, I., Malstrom, S. E., Tsichlis, P. N., Vogt, P. K., & Aoki, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204486 · Cited by 102 · see citing works

Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization

Murthy, S. S., Tosolini, A., Taguchi, T., et al. (2000) · Cytogenetic and Genome Research · doi:10.1159/000015481 · Cited by 63 · see citing works

Membrane translocation and activation of the Akt kinase in growth factor-stimulated hematopoietic cells

Testa, J. R., & Bellacosa, A. (1997) · Leukemia Research · doi:10.1016/s0145-2126(97)00093-3 · Cited by 29 · see citing works

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116 · see citing works

Apoptosis - the p53 network

Haupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136 · see citing works

Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation

Feng, J., Tamaskovic, R., Yang, Z., Brazil, D. P., Merlo, A., Hess, D., & Hemmings, B. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404936200 · Cited by 294 · see citing works

PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration

Chen, Y., Fan, Z., Wang, X., Mo, M., Zeng, S. B., Xu, R.-H., Wang, X., & Wu, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01650-6 · Cited by 130 · see citing works

Cellular lifespan and senescence signaling in embryonic stem cells

Miura, T., Mattson, M. P., & Rao, M. S. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00134.x · Cited by 102 · see citing works

Aberrant Expression of Apoptosis-Related Molecules in Endometriosis: A Possible Mechanism Underlying the Pathogenesis of Endometriosis

Nasu, K., Nishida, M., Kawano, Y., Tsuno, A., Abe, W., Yuge, A., Takai, N., & Narahara, H. (2011) · Reproductive Sciences · doi:10.1177/1933719110392059 · Cited by 73 · see citing works

Prognostic Significance of Activated AKT Expression in Soft-Tissue Sarcoma

Tomita, Y., Morooka, T., Hoshida, Y., Zhang, B., Qiu, Y., Nakamichi, I., Hamada, K.-I., Ueda, T., Naka, N., Kudawara, I., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1732 · Cited by 59 · see citing works

COL1A2 is a TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration

Omar, R., Cooper, A., Maranyane, H. M., Zerbini, L., & Prince, S. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.06.004 · Cited by 21 · see citing works

Time, agency and the Anthropocene

Randall, A. R. (2016) · Antiquity · doi:10.15184/aqy.2016.41 · Cited by 3 · see citing works

LibGuides: Anthropocene and Climate Change: Introduction

Payne, D. G. (2019)

LibGuides: Anthropocene and Climate Change: Journalism

Payne, D. G. (2019)

LibGuides: Anthropocene and Climate Change: Films

Zhang, C. (2019)

The Anthropocene: A Critical Exploration

Moore, A. (2015) · Environment and Society · doi:10.3167/ares.2015.060101 · Cited by 26 · see citing works