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Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes
Open accessAbstract
Cationic liposomes complexed with DNA (CL-DNA) are promising synthetically based nonviral carriers of DNA vectors for gene therapy. The solution structure of CL-DNA complexes was probed on length scales from subnanometer to micrometer by synchrotron x-ray diffraction and optical microscopy. The addition of either linear λ-phage or plasmid DNA to CLs resulted in an unexpected topological transition from liposomes to optically birefringent liquid-crystalline condensed globules. X-ray diffraction of the globules revealed a novel multilamellar structure with alternating lipid bilayer and DNA monolayers. The λ-DNA chains form a one-dimensional lattice with distinct interhelical packing regimes. Remarkably, in the isoelectric point regime, the λ-DNA interaxial spacing expands between 24.5 and 57.1 angstroms upon lipid dilution and is indicative of a long-range electrostatic-induced repulsion that is possibly enhanced by chain undulations.
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Cited by
Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221
Functional Liquid‐Crystalline Assemblies: Self‐Organized Soft Materials
Kato, T., Mizoshita, N., & Kishimoto, K. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200501384 · Cited by 1,545
Ionic Self‐Assembly: Facile Synthesis of Supramolecular Materials
Faul, C. F. J., & Antonietti, M. (2003) · Advanced Materials · doi:10.1002/adma.200300379 · Cited by 759
On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
Hafez, I., Maurer, N., & Cullis, P. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301506 · Cited by 601
Kurihara, K., Tamura, M., Shohda, K.-I., Toyota, T., Suzuki, K., & Sugawara, T. (2011) · Nature Chemistry · doi:10.1038/nchem.1127 · Cited by 559
Metadata
- Authors
- Rädler, J. O., Koltover, I., Salditt, T., & Safinya, C. R.
- Venue
- Science
- Published
- 1997-02-07
- Volume
- 275
- Issue
- 5301
- Pages
- 810-814
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045101135
- Cited by
- 1,410
- References
- 0
- FWCI
- 22.95
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes. https://app.cochat.ai/papers/10.1126/science.275.5301.810
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- Rädler, J. O., Koltover, I., Salditt, T., & Safinya, C. R. (1997). Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes. Science. https://doi.org/10.1126/science.275.5301.810
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