Lipid NanoparticlesFrom Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

The sequence of the human genome

Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909 · see citing works

Engineering precision nanoparticles for drug delivery

Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0090-8 · Cited by 7,933 · see citing works

Membrane lipids: where they are and how they behave

van Meer, G., Voelker, D. R., & Feigenson, G. W. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2330 · Cited by 7,157 · see citing works

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works

Stimuli-responsive nanocarriers for drug delivery

Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289 · see citing works

Recent advances with liposomes as pharmaceutical carriers

Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282 · see citing works

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., RINGOLD, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,954 · see citing works

Liposomal drug delivery systems: From concept to clinical applications

Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839 · see citing works

Doxil® — The first FDA-approved nano-drug: Lessons learned

Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792 · see citing works

mRNA vaccines — a new era in vaccinology

Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667 · see citing works

Diffusion of univalent ions across the lamellae of swollen phospholipids

Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664 · see citing works

Drug Delivery Systems: Entering the Mainstream

Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552 · see citing works

Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art

Müller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,759 · see citing works

Solid lipid nanoparticles Production, characterization and applications

Mehnert, W. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00105-3 · Cited by 3,158 · see citing works

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

Adams, D., Gonzalez-Duarte, A., O’Riordan, W. D., Yang, C.-C., Ueda, M., Kristen, A. V., Tournev, I., Schmidt, H. H., Coelho, T., Berk, J. L., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1716153 · Cited by 3,047 · see citing works

Structure of lipid bilayers

Nagle, J. F., & Tristram‐Nagle, S. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(00)00016-2 · Cited by 2,660 · see citing works

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1958-5 · Cited by 2,586 · see citing works

mRNA-based therapeutics--developing a new class of drugs

Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474 · see citing works

Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

Szoka, F. C., & Papahadjopoulos, D. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4194 · Cited by 2,333 · see citing works

Toxicity of cationic lipids and cationic polymers in gene delivery

Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.014 · Cited by 2,286 · see citing works

Liposomal Formulations in Clinical Use: An Updated Review

Bulbake, U., Doppalapudi, S., Kommineni, N., & Khan, W. (2017) · Pharmaceutics · doi:10.3390/pharmaceutics9020012 · Cited by 2,174 · see citing works

A review of stimuli-responsive nanocarriers for drug and gene delivery

Ganta, S., Devalapally, H., Shahiwala, A., & Amiji, M. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.017 · Cited by 2,157 · see citing works

Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations

Müller, R. H., Radtke, M., & Wissing, S. A. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00118-7 · Cited by 2,116 · see citing works

Tumor delivery of macromolecular drugs based on the EPR effect

Torchilin, V. P. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.011 · Cited by 2,032 · see citing works

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030 · see citing works

Active targeting schemes for nanoparticle systems in cancer therapeutics

Byrne, J. D., Betancourt, T., & Brannon‐Peppas, L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.08.005 · Cited by 1,732 · see citing works

Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

Torchilin, V. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4333 · Cited by 1,674 · see citing works

Model Systems, Lipid Rafts, and Cell Membranes

Simons, K., & Vaz, W. L. C. (2004) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.141803 · Cited by 1,671 · see citing works

Ligand-targeted therapeutics in anticancer therapy

Allen, T. M. (2002) · Nature reviews. Cancer · doi:10.1038/nrc903 · Cited by 1,648 · see citing works

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akinc, A., Maier, M. A., Manoharan, M., Fitzgerald, K., Jayaraman, M., Barros, S., Ansell, S., Du, X., Hope, M. J., Madden, T. D., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0591-y · Cited by 1,636 · see citing works

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

Papahadjopoulos, D., Allen, T. M., Gabizón, A., Mayhew, E. G., Matthay, K. K., Huang, S. K., Lee, K. D., Woodle, M. C., Lasiç, D. D., & Redemann, C. T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11460 · Cited by 1,621 · see citing works

New developments in liposomal drug delivery

Pattni, B. S., Chupin, V. V., & Torchilin, V. P. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00046 · Cited by 1,600 · see citing works

mRNA-lipid nanoparticle COVID-19 vaccines: structure and stability

Schoenmaker, L., Witzigmann, D., Kulkarni, J. A., Verbeke, R., Kersten, G., Jiskoot, W., & Crommelin, D. J. A. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120586 · Cited by 1,566 · see citing works

Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)

Szoka, F. C., & Papahadjopoulos, D. (1980) · Annual Review of Biophysics and Bioengineering · doi:10.1146/annurev.bb.09.060180.002343 · Cited by 1,515 · see citing works

Targeted drug delivery via the folate receptor

Sudimack, J. J., & Lee, R. J. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00062-9 · Cited by 1,477 · see citing works

Structure of DNA-Cationic Liposome Complexes: DNA Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes

Rädler, J. O., Koltover, I., Salditt, T., & Safinya, C. R. (1997) · Science · doi:10.1126/science.275.5301.810 · Cited by 1,411 · see citing works

Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid

Zabner, J., Fasbender, A., Moninger, T., Poellinger, K. A., & Welsh, M. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18997 · Cited by 1,408 · see citing works

Ethosomes — novel vesicular carriers for enhanced delivery: characterization and skin penetration properties

Touítou, E., Dayan, N., Bergelson, L. D., Godin, B., & Eliaz, M. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00222-9 · Cited by 1,350 · see citing works

Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress

Lammers, T., Kiessling, F., Hennink, W. E., & Storm, G. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.063 · Cited by 1,324 · see citing works

Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.

Felgner, J. H., Kumar, R., Sridhar, C. N., Wheeler, C. J., Tsai, Y.-L., Border, R., Ramsey, P., Martin, M. U., & Felgner, P. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41980-6 · Cited by 1,313 · see citing works

Encapsulation in the food industry: a review

Kermasha, S. (1999) · International Journal of Food Sciences and Nutrition · doi:10.1080/096374899101256 · Cited by 1,202 · see citing works

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

Low, P. S., Henne, W. A., & Doorneweerd, D. D. (2007) · Accounts of Chemical Research · doi:10.1021/ar7000815 · Cited by 1,174 · see citing works

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Kowalski, P. S., Rudra, A., Miao, L., & Anderson, D. G. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.012 · Cited by 1,127 · see citing works

Adriamycin

Blum, R. H., & CARTER, S. K. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-2-249 · Cited by 1,059 · see citing works

Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway

Qian, Z., Li, H., Sun, H., & Ho, K. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.4.561 · Cited by 1,021 · see citing works

Solid lipid nanoparticles: A modern formulation approach in drug delivery system

Mukherjee, S., Ray, S., & Thakur, R. S. (2009) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.57282 · Cited by 1,001 · see citing works

Phase transitions in phospholipid vesicles Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol

Papahadjopoulos, D., Jacobson, K., Nir, S., & Isac, I. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90314-3 · Cited by 998 · see citing works

Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia

Yatvin, M. B., Weinstein, J. N., Dennis, W. H., & Blumenthal, R. P. (1978) · Science · doi:10.1126/science.364652 · Cited by 959 · see citing works

Handbook of Biological Physics

Robillard, G. T., de Boer, H. F., Haris, P. I., Meijberg, W., Dijkstra, D. S., Schuurman‐Wolters, G. K., Hoeve-Duurkens, R. T., Chapman, D., & Broos, J. (1996) · Cited by 927 · see citing works

Trends and Developments in Liposome Drug Delivery Systems

Lian, T., & Ho, R. J. Y. (2001) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.1023 · Cited by 910 · see citing works

Gene therapy clinical trials worldwide to 2017: An update

Ginn, S. L., Amaya, A. K., Alexander, I. E., Edelstein, M., & Abedi, M. R. (2018) · The Journal of Gene Medicine · doi:10.1002/jgm.3015 · Cited by 903 · see citing works

Bioavailability of nanoparticles in nutrient and nutraceutical delivery

Acosta, E. (2008) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2008.01.002 · Cited by 876 · see citing works

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.

Pasqualini, R., Koivunen, E., Kain, R., Lahdenranta, J., Sakamoto, M., Stryhn, A., Ashmun, R., Shapiro, L., Arap, W., & Ruoslahti, E. I. (2000) · PubMed · Cited by 859 · see citing works

Handbook of Lipid Bilayers

Marsh, D. (2013) · CRC Press eBooks · doi:10.1201/b11712 · Cited by 849 · see citing works

Innovative approaches for cancer treatment: current perspectives and new challenges

Pucci, C., Martinelli, C., & Ciofani, G. (2019) · ecancermedicalscience · doi:10.3332/ecancer.2019.961 · Cited by 832 · see citing works

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

Sabnis, S., Kumarasinghe, E. S., Salerno, T., Mihai, C., Ketova, T., Senn, J. J., Lynn, A., Bulychev, A., McFadyen, I., Chan, J., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.03.010 · Cited by 820 · see citing works

Nutraceuticals: Facts and fiction

Espı́n, J. C., García‐Conesa, M., & Tomás-Barberán, F. A. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.09.014 · Cited by 814 · see citing works

Gene therapy clinical trials worldwide to 2012 – an update

Ginn, S., Alexander, I. E., Edelstein, M. L., Abedi, M. R., & Wixon, J. (2013) · Journal of Gene Medicine · doi:10.1002/jgm.2698 · Cited by 807 · see citing works

The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer

Farhood, H., Serbina, N. V., & Huang, L. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)80016-9 · Cited by 799 · see citing works

Bioavailability and Delivery of Nutraceuticals Using Nanotechnology

Huang, Q., Yu, H., & Ru, Q. (2009) · Journal of Food Science · doi:10.1111/j.1750-3841.2009.01457.x · Cited by 793 · see citing works

A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.

Needham, D., Anyarambhatla, G., Kong, G., & Dewhirst, M. W. (2000) · PubMed · Cited by 746 · see citing works

Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems

Yoo, J., Park, C., Yi, G., Lee, D., & Koo, H. (2019) · Cancers · doi:10.3390/cancers11050640 · Cited by 730 · see citing works

Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA.

Behr, J., DEMENEIX, B. A., Loeffler, J.-P., & Pérez-Mutul, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.6982 · Cited by 719 · see citing works

Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems

Mishra, V. K., Bansal, K. K., Verma, A., Yadav, N., Thakur, S., Sudhakar, K., & Rosenholm, J. M. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040191 · Cited by 704 · see citing works

Liposomes for the sustained drug release in vivo

Blume, G., & Cevc, G. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90440-y · Cited by 701 · see citing works

Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine

Al-Jamal, W. T., & Kostarelos, K. (2011) · Accounts of Chemical Research · doi:10.1021/ar200105p · Cited by 697 · see citing works

Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis.

Lee, R., & Low, P. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41848-5 · Cited by 694 · see citing works

Preparation, Characterization and Applications of Liposomes: State of the Art

Laouini, A., Jaafar‐Maalej, C., Limayem-Blouza, I., et al. (2012) · Journal of Colloid Science and Biotechnology · doi:10.1166/jcsb.2012.1020 · Cited by 693 · see citing works

Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN™) dispersions

Freitas, C., & Müller, R. H. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(98)00092-1 · Cited by 689 · see citing works

Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

Montoto, S. S., Muraca, G., & Ruiz, M. E. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.587997 · Cited by 672 · see citing works

Current Trends in The Use of Liposomes for Tumor Targeting

Deshpande, P. P., Biswas, S., & Torchilin, V. P. (2013) · Nanomedicine · doi:10.2217/nnm.13.118 · Cited by 663 · see citing works

Brain drug delivery of small molecules using immunoliposomes

Huwyler, J., Wu, D., & Pardridge, W. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14164 · Cited by 656 · see citing works

Novel methods for liposome preparation

Patil, Y. P., & Jadhav, S. (2013) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2013.10.011 · Cited by 640 · see citing works

Intrinsic curvature hypothesis for biomembrane lipid composition: a role for nonbilayer lipids.

Grüner, S. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3665 · Cited by 616 · see citing works

Pivotal Phase III Trial of Two Dose Levels of Denileukin Diftitox for the Treatment of Cutaneous T-Cell Lymphoma

Olsen, E. A., Duvic, M. A., Frankel, A. E., Kim, Y. H., Martin, A., Vonderheid, E. C., Jegasothy, B. V., Wood, G. S., Gordon, M., HEALD, P. W., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.2.376 · Cited by 610 · see citing works

Anti‐ <scp>PEG</scp> immunity: emergence, characteristics, and unaddressed questions

Yang, Q., & Lai, S. K. (2015) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1339 · Cited by 593 · see citing works

Nanopharmaceuticals (part 1): products on the market

Weissig, V., Pettinger, T. K., & Murdock, N. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s46900 · Cited by 591 · see citing works

Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery

Plank, C., Mechtler, K., Szoka, F. C., & Wagner, E. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.12-1437 · Cited by 584 · see citing works

Strategies, design, and chemistry in siRNA delivery systems

Dong, Y., Siegwart, D. J., & Anderson, D. G. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.05.004 · Cited by 581 · see citing works

Advanced strategies in liposomal cancer therapy: Problems and prospects of active and tumor specific drug release

Andresen, T. L., Jensen, S. S., & Jørgensen, K. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2004.12.001 · Cited by 580 · see citing works

Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization

Schwarz, C., Mehnert, W., Lucks, J. S., & Müller, R. H. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90047-7 · Cited by 574 · see citing works

The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors

Needham, D., & Dewhirst, M. W. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00233-2 · Cited by 572 · see citing works

Folate-targeted chemotherapy

Leamon, C. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.01.008 · Cited by 559 · see citing works

Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis.

Leamon, C. P., & Low, P. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5572 · Cited by 558 · see citing works

Chemistry of polyethylene glycol conjugates with biologically active molecules

Zalipsky, S. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00023-z · Cited by 553 · see citing works

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

Yanez Arteta, M., Kjellman, T., Bartesaghi, S., Wallin, S., Wu, X., Kvist, A. J., Dabkowska, A., Székely, N., Radulescu, A., Bergenholtz, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720542115 · Cited by 534 · see citing works

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment

García-Pinel, B., Porras-Alcalá, C., Ortega-Rodríguez, A., Sarabia, F., Prados, J. C., Melguizo, C., & López‐Romero, J. M. (2019) · Nanomaterials · doi:10.3390/nano9040638 · Cited by 530 · see citing works

Cubosomes: The Next Generation of Smart Lipid Nanoparticles?

Barriga, H. M. G., Holme, M. N., & Stevens, M. M. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201804067 · Cited by 507 · see citing works

Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.

Kong, G., Anyarambhatla, G., Petros, W. P., Braun, R. D., Colvin, O. M., Needham, D., & Dewhirst, M. W. (2000) · PubMed · Cited by 505 · see citing works

Zeta potential: a case study of cationic, anionic, and neutral liposomes

Smith, M. C., Crist, R. M., Clogston, J. D., & McNeil, S. E. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0527-z · Cited by 482 · see citing works

In vivo gene transfer via intravenous administration of cationic lipid–protamine–DNA (LPD) complexes

Li, S., & Huang, L. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300482 · Cited by 478 · see citing works

Targeting Folate Receptor with Folate Linked to Extremities of Poly(ethylene glycol)-Grafted Liposomes: In Vitro Studies

Gabizón, A., Horowitz, A. T., Goren, D., Tzemach, D., Mandelbaum-Shavit, F., Qazen, M. M., & Zalipsky, S. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801124 · Cited by 467 · see citing works

Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

Haider, M. A., Abdin, S. M., Kamal, L., & Orive, G. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030288 · Cited by 464 · see citing works

Solid lipid nanoparticles (SLN) : an alternative colloidal carrier system for controlled drug delivery

Müller, R. H., Mehnert, W., Lucks, J. S., Schwarz, C., Mühlen, A. Z., Meyhers, H., de Freitas, C. F., & Rühl, D. (1995) · European Journal of Pharmaceutics and Biopharmaceutics · Cited by 455 · see citing works

Life — As a Matter of Fat: The Emerging Science of Lipidomics

Mouritsen, O. G. (2005) · The Frontiers Collection · doi:10.1007/b138577 · Cited by 448 · see citing works

Liposome production by microfluidics: potential and limiting factors

Carugo, D., Bottaro, E., Owen, J., Stride, E., & Nastruzzi, C. (2016) · Scientific Reports · doi:10.1038/srep25876 · Cited by 443 · see citing works

Transferrin/transferrin receptor‐mediated drug delivery

Li, H., & Qian, Z. (2002) · Medicinal Research Reviews · doi:10.1002/med.10008 · Cited by 441 · see citing works

The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs

Nagayasu, A., Uchiyama, K., & Kiwada, H. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00041-1 · Cited by 438 · see citing works

Nanostructured lipid carriers system: Recent advances in drug delivery

Iqbal, M. A., Md, S., Sahni, J. K., Baboota, S., Dang, S., & Ali, J. (2012) · Journal of drug targeting · doi:10.3109/1061186x.2012.716845 · Cited by 437 · see citing works

Novel Process for Producing Cubic Liquid Crystalline Nanoparticles (Cubosomes)

Spicer, P. T., Hayden, K. L., Lynch, M. L., Ofori-Boateng, A., & Burns, J. L. (2001) · Langmuir · doi:10.1021/la010161w · Cited by 430 · see citing works

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

Chen, D. L., Love, K. T., Chen, Y., Eltoukhy, A. A., Kastrup, C. J., Sahay, G., Jeon, A., Dong, Y., Whitehead, K. A., & Anderson, D. G. (2012) · Journal of the American Chemical Society · doi:10.1021/ja301621z · Cited by 422 · see citing works

Regulatory aspects on nanomedicines

Sainz, V., Conniot, J., Matos, A. I., Peres, C., Zupanǒiǒ, E., Moura, L. I. F., Silva, L. C., Florindo, H. F., & Gaspar, R. S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.023 · Cited by 417 · see citing works

p H-Sensitive Liposomes: Possible Clinical Implications

Yatvin, M. B., Kreutz, W., Horwitz, B. A., & Shinitzky, M. (1980) · Science · doi:10.1126/science.7434025 · Cited by 415 · see citing works

Liposomes: an overview of manufacturing techniques.

Mozafari, M. R. (2005) · PubMed · Cited by 388 · see citing works

Recent advances in siRNA delivery mediated by lipid-based nanoparticles

Yonezawa, S., Koide, H., & Asai, T. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.022 · Cited by 386 · see citing works

Immunological and Toxicological Considerations for the Design of Liposomes

Inglut, C. T., Sorrin, A. J., Kuruppu, T., Vig, S., Cicalo, J., Ahmad, H., & Huang, H. (2020) · Nanomaterials · doi:10.3390/nano10020190 · Cited by 379 · see citing works

The Structure of DNA−Liposome Complexes

Lasiç, D. D., Strey, H. H., Stuart, M. C. A., Podgornik, R., & Frederik, P. M. (1997) · Journal of the American Chemical Society · doi:10.1021/ja962713g · Cited by 378 · see citing works

Characterization and potential applications of nanostructured aqueous dispersions

Yaghmur, A., & Glatter, O. (2008) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2008.07.007 · Cited by 373 · see citing works

Cubosomes: remarkable drug delivery potential

Karami, Z., & Hamidi, M. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.004 · Cited by 371 · see citing works

Liposomes: A Review of Manufacturing Techniques and Targeting Strategies

Maherani, B., Arab‐Tehrany, E., Mozafari, M. R., Gaïani, C., & Linder, M. (2011) · Current Nanoscience · doi:10.2174/157341311795542453 · Cited by 369 · see citing works

A comprehensive review on recent preparation techniques of liposomes

Has, C., & Sunthar, P. (2019) · Journal of Liposome Research · doi:10.1080/08982104.2019.1668010 · Cited by 366 · see citing works

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

Li, Y., Tenchov, R., Smoot, J., Liu, C., Watkins, S., & Zhou, Q. A. (2021) · ACS Central Science · doi:10.1021/acscentsci.1c00120 · Cited by 345 · see citing works

Solid lipid nanoparticles: a review on recent perspectives and patents

Paliwal, R., Paliwal, S. R., Kenwat, R., Kurmi, B. D., & Sahu, M. (2020) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2020.1720649 · Cited by 342 · see citing works

Liposomes in ultrasonic drug and gene delivery

Huang, S. L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.003 · Cited by 339 · see citing works

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

Duong, V., Nguyen, T., & Maeng, H. (2020) · Molecules · doi:10.3390/molecules25204781 · Cited by 339 · see citing works

State-of-the-art design and rapid-mixing production techniques of lipid nanoparticles for nucleic acid delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M. (2018) · Small Methods · doi:10.1002/smtd.201700375 · Cited by 332 · see citing works

Enzyme entrapment in liposomes

Gregoriadis, G. C., Leathwood, P. D., & Ryman, B. E. (1971) · FEBS Letters · doi:10.1016/0014-5793(71)80109-6 · Cited by 330 · see citing works

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Rahim, M. A., Jan, N., Khan, S., Shah, H., Madni, A., Khan, A., Jabar, A., Khan, S., Elhissi, A. M. A., Hussain, Z., et al. (2021) · Cancers · doi:10.3390/cancers13040670 · Cited by 330 · see citing works

Targeted therapy of cancer with radiolabeled antibodies.

Goldenberg, D. M. (2002) · PubMed · Cited by 318 · see citing works

Branched‐Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

Hajj, K. A., Ball, R. L., Deluty, S. B., Singh, S. R., Strelkova, D., Knapp, C. M., & Whitehead, K. A. (2019) · Small · doi:10.1002/smll.201805097 · Cited by 312 · see citing works

Formulation and application of a new generation of lipid nano-carriers for the food bioactive ingredients

Katouzian, I., Esfanjani, A. F., Jafari, S. M., et al. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.07.017 · Cited by 311 · see citing works

Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice.

Brekken, R. A., Overholser, J. P., Stastny, V., Waltenberger, J. L., Minna, J. D., & Thorpe, P. E. (2000) · PubMed · Cited by 310 · see citing works

Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery

Lamichhane, N., Udayakumar, T. S., D'Souza, W. D., Simone, C. B., Raghavan, S. R., Polf, J., & Mahmood, J. (2018) · Molecules · doi:10.3390/molecules23020288 · Cited by 304 · see citing works

Cubic Phase Nanoparticles (Cubosome): Principles for Controlling Size, Structure, and Stability

Barauskas, J., Johnsson, M., Joabsson, F., & Tiberg, F. (2005) · Langmuir · doi:10.1021/la047590p · Cited by 303 · see citing works

Evolution and clinical translation of drug delivery nanomaterials

Hassan, S., Prakash, G., Bal‐Öztürk, A., Saghazadeh, S., Sohail, M. F., Seo, J., Dokmeci, M. R., Zhang, Y. S., & Khademhosseini, A. (2017) · Nano Today · doi:10.1016/j.nantod.2017.06.008 · Cited by 288 · see citing works

Enhanced Hepatic Uptake of Liposomes Through Complement Activation Depending on the Size of Liposomes

Harashima, H., Sakata, K., Funato, K., & Kiwada, H. (1994) · Pharmaceutical Research · doi:10.1023/a:1018965121222 · Cited by 285 · see citing works

The origin of pegnology

Davis, F. F. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00021-2 · Cited by 279 · see citing works

Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery

Severino, P. B., Andreani, T., Macedo, A. S., et al. (2011) · Journal of Drug Delivery · doi:10.1155/2012/750891 · Cited by 277 · see citing works

Targeted delivery of doxorubicin using stealth liposomes modified with transferrin

Li, X., Ding, L., Xu, Y., Wang, Y., & Ping, Q. N. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.01.023 · Cited by 275 · see citing works

Cubosomes: An Overview

Garg, G., Saraf, S., & Saraf, S. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.350 · Cited by 266 · see citing works

Theranostic liposomes of TPGS coating for targeted co-delivery of docetaxel and quantum dots

Muthu, M. S., Kulkarni, S. A., Raju, A., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.036 · Cited by 265 · see citing works

Drug delivery and drug targeting with parenteral lipid nanoemulsions — A review

Hörmann, K., & Zimmer, A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.016 · Cited by 265 · see citing works

Liposomes Bearing Polyethyleneglycol-Coupled Transferrin with Intracellular Targeting Property to the Solid Tumors In Vivo

Ishida, O., Maruyama, K., Tanahashi, H., Iwatsuru, M., Sasaki, K., Eriguchi, M., & Yanagië, H. (2001) · Pharmaceutical Research · doi:10.1023/a:1010960900254 · Cited by 258 · see citing works

Catalase-loaded cisplatin-prodrug-constructed liposomes to overcome tumor hypoxia for enhanced chemo-radiotherapy of cancer

Zhang, R., Song, X., Liang, C., Yi, X., Song, G., Chao, Y., Yang, Y., Yang, K., Feng, L., & Liu, Z. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.025 · Cited by 255 · see citing works

Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals

Puglia, C., & Bonina, F. P. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.666967 · Cited by 254 · see citing works

Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity

Zhao, Y., Ren, W., Zhong, T., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.006 · Cited by 253 · see citing works

Phospholipid bilayers

Chapman, D. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80259-x · Cited by 248 · see citing works

Future directions of liposome- and immunoliposome-based cancer therapeutics

Park, J. W., Benz, C. C., & Martin, F. J. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.08.009 · Cited by 241 · see citing works

An Address System in the Vasculature of Normal Tissues and Tumors

Ruoslahti, E. I., & Rajotte, D. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.813 · Cited by 239 · see citing works

Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome to target chemotherapeutics to tumor

Manjappa, A. S., Chaudhari, K. R., Venkataraju, M. P., et al. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.002 · Cited by 236 · see citing works

Therapeutic nucleic acids: current clinical status

Sridharan, K., & Gogtay, N. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12987 · Cited by 230 · see citing works

Designing nanomedicine for immuno-oncology

Jiang, W., Roemeling, C. A. V., Chen, Y., Qie, Y., Liu, X., Chen, J., & Kim, B. Y. S. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0029 · Cited by 229 · see citing works

Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives

Gómez-Aguado, I., Rodríguez-Castejón, J., Vicente-Pascual, M., Rodríguez‐Gascón, A., Solinís, M. Á., & del Pozo‐Rodríguez, A. (2020) · Nanomaterials · doi:10.3390/nano10020364 · Cited by 224 · see citing works

Progress in liquid crystalline dispersions: Cubosomes

Spicer, P. T. (2005) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2005.09.004 · Cited by 216 · see citing works

Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy

Faustino, C. M. C., & Pinheiro, L. M. V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12010029 · Cited by 207 · see citing works

Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic drugs

Narang, J., Khan, S., Baboota, S., et al. (2015) · International Journal of Pharmaceutical Investigation · doi:10.4103/2230-973x.167661 · Cited by 204 · see citing works

Large volume liposomes by an ether vaporization method

Deamer, D. W., & Bangham, A. D. (1976) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(76)90527-x · Cited by 203 · see citing works

Formation of stable cationic lipid/DNA complexes for gene transfer.

Hofland, H. E. J., Shephard, L. B., & Sullivan, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7305 · Cited by 200 · see citing works

Enhancement of the Phase Transition Permeability of DPPC Liposomes by Incorporation of MPPC: A New Temperature-Sensitive Liposome for use with Mild Hyperthermia

Anyarambhatla, G., & Needham, D. (1999) · Journal of Liposome Research · doi:10.3109/08982109909035549 · Cited by 199 · see citing works

A general method for the introduction of enzymes, by means of immunoglobulin-coated liposomes, into lysosomes of deficient cells.

Weissmann, G., Bloomgarden, D., Kaplan, R., Cohen, C. M., Hoffstein, S. T., Collins, T., Gotlieb, A. I., & Nagle, D. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.1.88 · Cited by 191 · see citing works

Advances in Receptor‐Mediated, Tumor‐Targeted Drug Delivery

Large, D. E., Soucy, J. R., Hebert, J. M., & Auguste, D. T. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800091 · Cited by 189 · see citing works

Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds

Borges, A., de Freitas, V. A. P., Mateus, N. F. D. C. B., Fernandes, I., & Oliveira, J. (2020) · Antioxidants · doi:10.3390/antiox9100998 · Cited by 187 · see citing works

Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing

Zhang, X., Zhao, W., Nguyen, G. N., Zhang, C., Zeng, C., Yan, J., Du, S., Hou, X., Li, W., Jiang, J., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc2315 · Cited by 183 · see citing works

Recent progress in the study of the interactions of amphotericin B with cholesterol and ergosterol in lipid environments

Kamiński, D. M. (2014) · European Biophysics Journal · doi:10.1007/s00249-014-0983-8 · Cited by 182 · see citing works

Transferrin As A Targeting Ligand for Liposomes and Anticancer Drugs

Singh, M. S. (1999) · Current Pharmaceutical Design · doi:10.2174/138161280506230110111312 · Cited by 181 · see citing works

Lipid-Core Micelles for Targeted Drug Delivery

Torchilin, V. P. (2005) · Current Drug Delivery · doi:10.2174/156720105774370221 · Cited by 179 · see citing works

Development of Inherently Echogenic Liposomes as an Ultrasonic Contrast Agent†

Alkan-Önyüksel, H., Demos, S. M., Lanza, G. M., et al. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js950407f · Cited by 175 · see citing works

Tyrosine Kinase Inhibitors Targeted to the Epidermal Growth Factor Receptor Subfamily

Noonberg, S. B., & Benz, C. C. (2000) · Drugs · doi:10.2165/00003495-200059040-00003 · Cited by 173 · see citing works

Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals

Souto, E. B., Fernandes, A. R., Martins‐Gomes, C., Coutinho, T. E., Durazzo, A., Lucarini, M., Souto, S. B., Silva, A. M., & Santini, A. (2020) · Applied Sciences · doi:10.3390/app10051594 · Cited by 169 · see citing works

An intracellular lamellar–nonlamellar phase transition rationalizes the superior performance of some cationic lipid transfection agents

Koynova, R. D., Wang, L., & MacDonald, R. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603085103 · Cited by 164 · see citing works

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside

Zatsepin (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s106625 · Cited by 162 · see citing works

Lipoplex-mediated delivery of nucleic acids: factors affecting in vivo transfection

Dass, C. R. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0558-8 · Cited by 159 · see citing works

Pharmacological-toxicological expert report. CAELYX. (Stealth liposomal doxorubicin HCl).

Working, P. K., & Dayan, A. D. (1996) · PubMed · Cited by 156 · see citing works

Theranostics: Are We There Yet?

Svenson, S. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300644n · Cited by 155 · see citing works

General features of phospholipid phase transitions

Marsh, D. (1991) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(91)90071-i · Cited by 154 · see citing works

Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.

Salvatore, G., Beers, R., Margulies, I., Kreitman, R. J., & Pastan, I. H. (2002) · PubMed · Cited by 153 · see citing works

Phase II Trial of Murine 131I-Labeled Antitenascin Monoclonal Antibody 81C6 Administered Into Surgically Created Resection Cavities of Patients With Newly Diagnosed Malignant Gliomas

Reardon, D. A., Akabani, G., Coleman, R. E., Friedman, A. H., Friedman, H. S., Herndon, J. E., Cokgor, I., McLendon, R. E., Pegram, C. N., Provenzale, J. M., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.5.1389 · Cited by 152 · see citing works

Nanotheranostics – a review of recent publications

Ho, J. A., Wang, L., & Chuang, M.-C. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s33065 · Cited by 144 · see citing works

Materials characterization of the low temperature sensitive liposome (LTSL): effects of the lipid composition (lysolipid and DSPE–PEG2000) on the thermal transition and release of doxorubicin

Needham, D., Park, J.-Y., Wright, A. M., & Tong, J. (2012) · Faraday Discussions · doi:10.1039/c2fd20111a · Cited by 141 · see citing works

Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia

Nabhan, J. F., Wood, K. M., Rao, V. P., Morin, J., Bhamidipaty, S., LaBranche, T. P., Gooch, R. L., Bozal, F., Bulawa, C. E., & Guild, B. C. (2016) · Scientific Reports · doi:10.1038/srep20019 · Cited by 140 · see citing works

Effect of liposome size and drug release properties on pharmacokinetics of encapsulated drug in rats.

Allen, T. M., & Everest, J. M. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21638-x · Cited by 137 · see citing works

Physical and Biological Properties of Cationic Triesters of Phosphatidylcholine

MacDonald, R. C., Ashley, G. W., Shida, M. M., Rakhmanova, V. A., Tarahovsky, Y. S., Pantazatos, D., Kennedy, M. T., Pozharski, E. V., Baker, K. A., Jones, R. D., et al. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77095-5 · Cited by 135 · see citing works

Applications of nanoparticles in topical drug delivery and in cosmetics

Wu, X. Y., & Guy, R. H. (2009) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(09)50080-9 · Cited by 126 · see citing works

Liposomes as targetable drug carriers.

Vp, T. (1985) · PubMed · Cited by 125 · see citing works

A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma.

Messmann, R. A., Vitetta, E. S., Headlee, D. J., et al. (2000) · PubMed · Cited by 120 · see citing works

Mechanism of the selective toxicity of amphotericin B incorporated into liposomes.

Juliano, R. L., Grant, C. W. M., Barber, K. R., & Kalp, M. A. (1987) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10311-8 · Cited by 118 · see citing works

Targeting of Nanoparticles: Folate Receptor

Kularatne, S. A., & Low, P. S. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-609-2_17 · Cited by 113 · see citing works

Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy

Zhang, B., Wang, F., Zhou, H., Gao, D., Yuan, Z., Wu, C., & Zhang, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201813066 · Cited by 113 · see citing works

Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety

Vlatkovic, I. (2021) · Biomedicines · doi:10.3390/biomedicines9050530 · Cited by 112 · see citing works

PEG–lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication

Gill, K. K., Kaddoumi, A., & Nazzal, S. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2014.997735 · Cited by 109 · see citing works

Lipid nanocarriers for microRNA delivery

Scheideler, M., Vidaković, I., & Prassl, R. (2019) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2019.104837 · Cited by 107 · see citing works

Controlled Synthesis of Mixed Core and Layered (Zn,Cd)S and (Hg,Cd)S Nanocrystals within Phosphatidylcholine Vesicles

Korgel, B. A., & Monbouquette, H. G. (2000) · Langmuir · doi:10.1021/la990139r · Cited by 104 · see citing works

DNA Release from Lipoplexes by Anionic Lipids: Correlation with Lipid Mesomorphism, Interfacial Curvature, and Membrane Fusion

Tarahovsky, Y. S., Koynova, R. D., & MacDonald, R. C. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.042895 · Cited by 104 · see citing works

Long term survival of patients with advanced ovarian cancer treated with intraperitoneal radioimmunotherapy

Epenetos, A. A., Hird, V., Lambert, H. E., et al. (2000) · International Journal of Gynecological Cancer · doi:10.1046/j.1525-1438.2000.99510.x · Cited by 104 · see citing works

Toward a magic or imaginary bullet? Ligands for drug targeting to cancer cells: principles, hopes, and challenges

Sikorski, A. F., Toporkiewicz, M., Meissner, J. M., Matusewicz, L., & Czogalla, A. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s74514 · Cited by 104 · see citing works

Quality-of-Life Improvements in Cutaneous T-Cell Lymphoma Patients Treated with Denileukin Diftitox (ONTAK®)

Duvic, M. A., Kuzel, T. M., Olsen, E. A., Martin, A., Foss, F. M., Kim, Y. H., HEALD, P. W., Bacha, P., NICHOLS, J. C., & Liepa, A. M. (2002) · Clinical Lymphoma · doi:10.3816/clm.2002.n.003 · Cited by 99 · see citing works

Her2-targeted pegylated liposomal doxorubicin: Retention of target-specific binding and cytotoxicity after in vivo passage

Shmeeda, H., Tzemach, D., Mak, L., & Gabizón, A. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.02.002 · Cited by 98 · see citing works

Nano-engineering of 5-fluorouracil-loaded magnetoliposomes for combined hyperthermia and chemotherapy against colon cancer

Clares, B., Biedma-Ortiz, R. A., Sáez-Fernández, E., et al. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.01.028 · Cited by 94 · see citing works

The concept of sentinel node localization: How it started

Morton, D. L., & Chan, A. D. (2000) · Seminars in Nuclear Medicine · doi:10.1016/s0001-2998(00)80056-2 · Cited by 94 · see citing works

Physical correlates of the ultrasonic reflectivity of lipid dispersions suitable as diagnostic contrast agents

Huang, S.-L., Hamilton, A. J., Pozharski, E. V., et al. (2002) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(01)00512-9 · Cited by 90 · see citing works

Liposomes in Drug Delivery: How It All Happened

Gregoriadis, G. C. (2016) · Pharmaceutics · doi:10.3390/pharmaceutics8020019 · Cited by 90 · see citing works

Detecting infection and inflammation with technetium-99m-labeled Stealth liposomes.

Oyen, W. J. G., Boerman, O. C., Storm, G., van Bloois, L., Koenders, E. B., Claessens, R. A. M. J., Perenboom, R. M., Crommelin, D. J. A., van der Meer, J. W. M., & Corstens, F. H. M. (1996) · PubMed · Cited by 88 · see citing works

Solid lipid nanoparticles for applications in gene therapy: a review of the state of the art

Bondı̀, M. L., & Craparo, E. F. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903362410 · Cited by 85 · see citing works

Near-infrared light-triggered drug release from a multiple lipid carrier complex using an all-in-one strategy

Li, H., Yang, X., Zhou, Z., Wang, K., Li, C., Qiao, H., Oupický, D., & Sun, M. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.06.029 · Cited by 83 · see citing works

Analytical Methods for the Characterization of Cationic Lipid–Nucleic Acid Complexes

Ferrari, M. E., Nguyen, C. M., Zelphati, O., et al. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.3-341 · Cited by 82 · see citing works

Transferrin-mediated targeting of hypericin embedded in sterically stabilized PEG-liposomes

Derycke, A., & de Witte, P. A. M. (2002) · International Journal of Oncology · doi:10.3892/ijo.20.1.181 · Cited by 81 · see citing works

Structure of in‐serum transfecting DNA–cationic lipid complexes

Boukhnikachvili, T., Aguerre-Chariol, O., Airiau, M., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00505-x · Cited by 80 · see citing works

O‐ethylphosphatidylcholine: A metabolizable cationic phospholipid which is a serum‐compatible DNA transfection agent

MacDonald, R. C., Rakhmanova, V. A., Choi, K. L., et al. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js990006q · Cited by 80 · see citing works

Nanoparticle delivery of a peptide targeting EGFR signaling

Kim, S. K., & Huang, L. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.014 · Cited by 75 · see citing works

Smart nanoparticles for cancer therapy

Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works

Advances in COVID-19 mRNA vaccine development

Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601 · see citing works

mRNA-based cancer therapeutics

Liu, C., Shi, Q., Huang, X., Koo, S., Kong, N., & Tao, W. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-023-00586-2 · Cited by 500 · see citing works

Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of <i>in vivo</i> imaging

Jung, H. N., Lee, S.-Y., Lee, S., Youn, H., & Im, H.-J. (2022) · Theranostics · doi:10.7150/thno.77259 · Cited by 282 · see citing works

Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

Waheed, S., Li, Z., Zhang, F., Chiarini, A., Armato, U., & Wu, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01605-4 · Cited by 259 · see citing works

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

Domingues, C., Santos, A., Alvarez-Lorenzo, C., Concheiro, A., Jarak, I., Veiga, F., Barbosa, I., Dourado, M., & Figueiras, A. (2022) · ACS Nano · doi:10.1021/acsnano.2c00128 · Cited by 235 · see citing works

Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems

Xu, C., Ban, Q., Wang, W., Hou, J., & Jiang, Z. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.061 · Cited by 225 · see citing works

Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) on Nanoparticle Formulation: Implications for COVID-19 Vaccines

Padín-González, E., Lancaster, P., Bottini, M., Gasco, P., Tran, L., Fadeel, B., Wilkins, T., & Monopoli, M. P. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.882363 · Cited by 166 · see citing works

Rise of the RNA machines – self-amplification in mRNA vaccine design

Comes, J. D. G., Pijlman, G. P., & Hick, T. A. H. (2023) · Trends in Biotechnology · doi:10.1016/j.tibtech.2023.05.007 · Cited by 87 · see citing works

Self-Amplifying RNA Approach for Protein Replacement Therapy

Papukashvili, D., Rcheulishvili, N., Liu, C., Ji, Y., He, Y., & Wang, P. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112884 · Cited by 76 · see citing works

Development of Novel siRNA Therapeutics: A Review with a Focus on Inclisiran for the Treatment of Hypercholesterolemia

Ebenezer, O., Comoglio, P., Wong, G. K.-S., & Tuszynski, J. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044019 · Cited by 39 · see citing works

Clinical translation of nanomedicines for brain diseases: Current challenges and future directions

Wang, G., Wang, N., Xia, X., Ismail, M., & Shi, B. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114426 · Cited by 33 · see citing works

An overview on nanoplatforms for statins delivery: Perspectives for safe and effective therapy

Etemad, L., Salmasi, Z., Moosavian Kalat, S. A., Moshiri, M., Zamanian, J., Kesharwani, P., & Sahebkar, A. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116572 · Cited by 18 · see citing works

Placental Drug Delivery to Treat Pre‐Eclampsia and Fetal Growth Restriction

Deepak, V., El‐Balawi, L., & Harris, L. K. (2024) · Small · doi:10.1002/smll.202311165 · Cited by 16 · see citing works

The emergence of nanocarriers in the management of diseases and disorders

Khulbe, P., Singh, D., Aman, A., et al. (2023) · Community Acquired Infection · doi:10.54844/cai.2022.0139 · Cited by 5 · see citing works

Delivery of Doxorubicin Using Double-Layered Core–Shell Nanocarrier Based on Magnetic Fe 3 O 4 Core and Salep Shells

Hosseini, S. H., Alipour, S., & Zohreh, N. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b02390 · Cited by 20 · see citing works

Strategies for ligand-installed nanocarriers

Miyazaki, T., Nakagawa, Y., & Cabral, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821506-7.00024-7 · Cited by 3 · see citing works

Development and evaluation of lipid nanocarriers for quercetin delivery: A comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE)

Aditya, N. P., Macedo, A. S., Doktorovová, S., Souto, E. B., Kim, S., Chang, P., & Ko, S. (2014) · LWT · doi:10.1016/j.lwt.2014.04.058 · Cited by 293 · see citing works

Ligand decorated biodegradable nanomedicine in the treatment of cancer

Ahmad, E., Ali, A., Fatima, M. T., Nimisha, Apurva, A., Kumar, A., Sumi, M. P., Sattar, R. S. A., Mahajan, B., & Saluja, S. S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105544 · Cited by 33 · see citing works