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Single Molecule Force Spectroscopy on Polysaccharides by Atomic Force Microscopy
Abstract
Recent developments in piconewton instrumentation allow the manipulation of single molecules and measurements of intermolecular as well as intramolecular forces. Dextran filaments linked to a gold surface were probed with the atomic force microscope tip by vertical stretching. At low forces the deformation of dextran was found to be dominated by entropic forces and can be described by the Langevin function with a 6 angstrom Kuhn length. At elevated forces the strand elongation was governed by a twist of bond angles. At higher forces the dextran filaments underwent a distinct conformational change. The polymer stiffened and the segment elasticity was dominated by the bending of bond angles. The conformational change was found to be reversible and was corroborated by molecular dynamics calculations.
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Cited by
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Hugel, T., Holland, N. B., Cattani, A., Moroder, L., Seitz, M., & Gaub, H. E. (2002) · Science · doi:10.1126/science.1069856 · Cited by 836
Self-citationPolysaccharide elasticity governed by chair–boat transitions of the glucopyranose ring
Marszalek, P. E., Oberhauser, A. F., Pang, Y.-P., & Fernandez, J. M. (1998) · Nature · doi:10.1038/25322 · Cited by 451
Ribas-Arino, J., & Marx, D. (2012) · Chemical Reviews · doi:10.1021/cr200399q · Cited by 448
Long range interactions in nanoscale science
French, R. H., Parsegian, V. A., Podgornik, R., Rajter, R. F., Jagota, A., Luo, J., Asthagiri, D., Chaudhury, M. K., Chiang, Y.-M., Granick, S., et al. (2010) · Reviews of Modern Physics · doi:10.1103/revmodphys.82.1887 · Cited by 441
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Metadata
- Authors
- Rief, M., Oesterhelt, F., Heymann, B., & Gaub, H. E.
- Venue
- Science
- Published
- 1997-02-28
- Volume
- 275
- Issue
- 5304
- Pages
- 1295-1297
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015667791
- Cited by
- 1,124
- References
- 0
- FWCI
- 36.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rief, M., Oesterhelt, F., Heymann, B., & Gaub, H. E. (1997). Single Molecule Force Spectroscopy on Polysaccharides by Atomic Force Microscopy. Science. https://doi.org/10.1126/science.275.5304.1295
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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