The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Stem Cells in the Central Nervous System
Abstract
In the vertebrate central nervous system, multipotential cells have been identified in vitro and in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the magnitude of which is sufficient to account for the number of cells in the brain. Factors that control the differentiation of fetal stem cells to neurons and glia have been defined in vitro, and multipotential cells with similar signaling logic can be cultured from the adult central nervous system. Transplanting cells to new sites emphasizes that neuroepithelial cells have the potential to integrate into many brain regions. These results focus attention on how information in external stimuli is translated into the number and types of differentiated cells in the brain. The development of therapies for the reconstruction of the diseased or injured brain will be guided by our understanding of the origin and stability of cell type in the central nervous system.
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Cites
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Thomas, K. R., & Capecchi, M. R. (1990) · Nature · doi:10.1038/346847a0 · Cited by 896
Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor
Cattaneo, E., & McKay, R. (1990) · Nature · doi:10.1038/347762a0 · Cited by 717
Self-citationMetabolic and Genetic Analyses of Apoptosis in Potassium/Serum-Deprived Rat Cerebellar Granule Cells
Miller, T. M., & Johnson Jr., E. M. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07487.1996 · Cited by 228
Cited by
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Aboody, K. S., Brown, A., Rainov, N. G., Bower, K. A., Liu, S., Yang, W., Small, J. E., Herrlinger, U., Ourednik, V., Black, P. M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12846 · Cited by 1,207
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054
Jin, K., Minami, M., Lan, J. Q., Mao, X. O., Batteur, S., Simon, R. P., & Greenberg, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081011098 · Cited by 1,051
Trejo, J. L., Carro, E., & Torres-Alemán, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01628.2001 · Cited by 1,017
Metadata
- Authors
- McKay, R.
- Venue
- Science
- Published
- 1997-04-04
- Volume
- 276
- Issue
- 5309
- Pages
- 66-71
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2164986141
- Cited by
- 1,472
- References
- 5
- FWCI
- 24.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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