The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Amphibian Limb Regeneration: Rebuilding a Complex Structure
Abstract
The ability to regenerate complex structures is widespread in metazoan phylogeny, but among vertebrates the urodele amphibians are exceptional. Adult urodeles can regenerate their limbs by local formation of a mesenchymal growth zone or blastema. The generation of blastemal cells depends not only on the local extracellular environment after amputation or wounding but also on the ability to reenter the cell cycle from the differentiated state. The blastema replaces structures appropriate to its proximodistal position. Axial identity is probably encoded as a graded property that controls cellular growth and movement through local cell interactions. The molecular basis is not understood, but proximodistal identity in newt blastemal cells may be respecified by signaling through a retinoic acid receptor isoform. The possibility of inducing a blastema on a mammalian limb cannot be discounted, although the molecular constraints are becoming clearer as we understand more about the mechanisms of urodele regeneration.
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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062
Sonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,307
French, V., Bryant, P. J., & Bryant, S. V. (1976) · Science · doi:10.1126/science.948762 · Cited by 866
Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A., & Tabin, C. (1994) · Cell · doi:10.1016/0092-8674(94)90030-2 · Cited by 803
Gu, W., Schneider, J. W., Condorelli, G., Kaushal, S., Mahdavi, V., & Nadal-Ginard, B. (1993) · Cell · doi:10.1016/0092-8674(93)90110-c · Cited by 729
A positive feedback loop coordinates growth and patterning in the vertebrate limb
Niswander, L., Jeffrey, S., Martin, G. R., & Tickle, C. (1994) · Nature · doi:10.1038/371609a0 · Cited by 698
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
Morgenbesser, S. D., Williams, B. O., Jacks, T., & DePinho, R. A. (1994) · Nature · doi:10.1038/371072a0 · Cited by 610
Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression
Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547
(1969) · Elsevier eBooks · doi:10.1016/c2013-0-12497-x · Cited by 479
Inhibition of Myogenic Differentiation in Proliferating Myoblasts by Cyclin D1-Dependent Kinase
Skapek, S. X., Rhee, J., Spicer, D. B., & Lassar, A. B. (1995) · Science · doi:10.1126/science.7863328 · Cited by 477
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The Evolving Concept of a Stem Cell
Blau, H. M., Brazelton, T. R., & Weimann, J. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00409-3 · Cited by 1,046
Metcalfe, A. D., & Ferguson, M. W. J. (2007) · Journal of The Royal Society Interface · doi:10.1098/rsif.2006.0179 · Cited by 785
Gli and hedgehog in cancer: tumours, embryos and stem cells
Ruiz i Altaba, A., Sánchez, P., & Dahmane, N. (2002) · Nature Reviews Cancer · doi:10.1038/nrc796 · Cited by 708
Effenhauser, C. S., Bruin, G. J. M., Paulus, A., & Ehrat, M. (1997) · Analytical Chemistry · doi:10.1021/ac9703919 · Cited by 640
Li, Y., Foster, W., Deasy, B. M., Chan, Y., Prisk, V., Tang, Y., Cummins, J., & Huard, J. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63188-4 · Cited by 451
Metadata
- Authors
- Brockes, J. P.
- Venue
- Science
- Published
- 1997-04-04
- Volume
- 276
- Issue
- 5309
- Pages
- 81-87
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981692093
- Cited by
- 484
- References
- 59
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
