The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Gli and hedgehog in cancer: tumours, embryos and stem cells
Open accessAbstract
Do tumours arise from stem cells, or are they derived from more differentiated cells that, for some reason, begin to recapitulate developmental programmes? Inappropriate activation of the Sonic hedgehog–Gli signalling pathway occurs in several types of tumour, including those of the brain and the skin. Studies in these and other systems suggest that inappropriate function of the Gli transcription factors in stem or precursor cells might lead to the onset of a tumorigenic programme and that these factors are prime targets for anticancer therapies.
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Cites
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
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Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
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Fisher, G. H., Wellen, S. L., Klimstra, D., Lenczowski, J. M., Tichelaar, J. W., Lizak, M. J., Whitsett, J. A., Koretsky, A., & Varmus, H. E. (2001) · Genes & Development · doi:10.1101/gad.947701 · Cited by 582
Hedgehog–GLI signaling and the growth of the brain
Ruiz i Altaba, A., Palma, V., & Dahmane, N. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn704 · Cited by 376
Self-citationSato, N., Leopold, P. L., & Crystal, R. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7691 · Cited by 253
Cited by
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
“Many of the genes are astrocyte-enriched, although only three (Rfx4, Pbxip1, and Gli3) meet our criteria for being astrocyte-specific (at least 20-fold astrocyte-enriched).”
BackgroundThe mechanisms of Hedgehog signalling and its roles in development and disease
Briscoe, J., & Thérond, P. P. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3598 · Cited by 1,751
Cancer stem cells in nervous system tumors
Singh, S. K., Clarke, I. D., Hide, T., & Dirks, P. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207946 · Cited by 569
FoxM1: At the crossroads of ageing and cancer
Laoukili, J., Stahl, M., & Medema, R. H. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.006 · Cited by 377
REN KCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
Di Marcotullio, L., Ferretti, E., De Smaele, E., Argenti, B., Mincione, C., Zazzeroni, F., Gallo, R., Masuelli, L., Napolitano, M., Maroder, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400690101 · Cited by 179
Metadata
- Authors
- Ruiz i Altaba, A., Sánchez, P., & Dahmane, N.
- Venue
- Nature Reviews Cancer
- Published
- 2002-05-01
- Volume
- 2
- Issue
- 5
- Pages
- 361-372
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2039640335
- Cited by
- 708
- References
- 7
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
