The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Rescue of a Drosophila NF1 Mutant Phenotype by Protein Kinase A
Abstract
The neurofibromatosis type 1 (NF1) tumor suppressor protein is thought to restrict cell proliferation by functioning as a Ras-specific guanosine triphosphatase–activating protein. However, Drosophila homozygous for null mutations of an NF1 homolog showed no obvious signs of perturbed Ras1-mediated signaling. Loss of NF1 resulted in a reduction in size of larvae, pupae, and adults. This size defect was not modified by manipulating Ras1 signaling but was restored by expression of activated adenosine 3′,5′-monophosphate–dependent protein kinase (PKA). Thus, NF1 and PKA appear to interact in a pathway that controls the overall growth of Drosophila.
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Citations
Cites
The neurofibromatosis type 1 gene encodes a protein related to GAP
Xu, G., O'Connell, P., Viskochil, D., Cawthon, R., Robertson, M., Culver, M., Dunn, D., Stevens, J., Gesteland, R., White, R., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90024-9 · Cited by 1,095
Brannan, C. I., Perkins, A. S., Vogel, K. S., Ratner, N., Nordlund, M. L., Reid, S. W., Buchberg, A. M., Jenkins, N. A., Parada, L. F., & Copeland, N. G. (1994) · Genes & Development · doi:10.1101/gad.8.9.1019 · Cited by 641
Cited by
Comparative Genomics of the Eukaryotes
Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698
Self-citationNF1 Tumor Suppressor Gene Function
Cichowski, K., & Jacks, T. (2001) · Cell · doi:10.1016/s0092-8674(01)00245-8 · Cited by 601
A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor
Ratner, N., & Miller, S. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3911 · Cited by 493
Insights into the pathogenesis of neurofibromatosis 1 vasculopathy
Hamilton, S., & Friedman, J. (2000) · Clinical Genetics · doi:10.1034/j.1399-0004.2000.580501.x · Cited by 280
Caldwell, P. E., Walkiewicz, M., & Stern, M. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.011 · Cited by 267
Metadata
- Authors
- The, I., Hannigan, G. E., Cowley, G. S., Reginald, S., Zhong, Y., Gusella, J. F., Hariharan, I. K., & Bernards, A.
- Venue
- Science
- Published
- 1997-05-02
- Volume
- 276
- Issue
- 5313
- Pages
- 791-794
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1487661416
- Cited by
- 255
- References
- 2
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- The, I., Hannigan, G. E., Cowley, G. S., Reginald, S., Zhong, Y., Gusella, J. F., Hariharan, I. K., & Bernards, A. (1997). Rescue of a Drosophila NF1 Mutant Phenotype by Protein Kinase A. Science. https://doi.org/10.1126/science.276.5313.791
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