The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog
Abstract
Mutations in the tumor suppressor gene PATCHED ( PTC ) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. Gene regulatory relationships defined in the fruit fly Drosophila suggest that overproduction of Sonic hedgehog (SHH), the ligand for PTC, will mimic loss of ptc function. It is shown here that transgenic mice overexpressing SHH in the skin develop many features of basal cell nevus syndrome, demonstrating that SHH is sufficient to induce basal cell carcinomas in mice. These data suggest that SHH may have a role in human tumorigenesis.
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Citations
Cites
A genetic model for colorectal tumorigenesis
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Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
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Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
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Self-citationBitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
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Self-citationThe role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
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Cited by
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Self-citationDe Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
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1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., et al. (2000) · Nature Genetics · doi:10.1038/74231 · Cited by 737
Vasioukhin, V., Degenstein, L., Wise, B., & Fuchs, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8551 · Cited by 608
Metadata
- Authors
- Oro, A. E., Higgins, K. M., Hu, Z., Bonifas, J. M., Epstein, E. H., & Scott, M. P.
- Venue
- Science
- Published
- 1997-05-02
- Volume
- 276
- Issue
- 5313
- Pages
- 817-821
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2140619393
- Cited by
- 710
- References
- 37
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog. https://app.cochat.ai/papers/10.1126/science.276.5313.817
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- Oro, A. E., Higgins, K. M., Hu, Z., Bonifas, J. M., Epstein, E. H., & Scott, M. P. (1997). Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog. Science. https://doi.org/10.1126/science.276.5313.817
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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