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Polarization-Enhanced NMR Spectroscopy of Biomolecules in Frozen Solution
Abstract
Large dynamic nuclear polarization signal enhancements (up to a factor of 100) were obtained in the solid-state magic-angle spinning nuclear magnetic resonance (NMR) spectra of arginine and the protein T4 lysozyme in frozen glycerol-water solutions with the use of dynamic nuclear polarization. Polarization was transferred from the unpaired electrons of nitroxide free radicals to nuclear spins through microwave irradiation near the electron paramagnetic resonance frequency. This approach may be a generally applicable signal enhancement scheme for the high-resolution solid-state NMR spectroscopy of biomolecules.
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Cited by
Surface Enhanced NMR Spectroscopy by Dynamic Nuclear Polarization
Lesage, A., Lelli, M., Gajan, D., Caporini, M. A., Vitzthum, V., Miéville, P., Alauzun, J., Roussey, A., Thieuleux, C., Mehdi, A., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja104771z · Cited by 585
Dynamic nuclear polarization for sensitivity enhancement in modern solid-state NMR
Lilly Thankamony, A. S., Wittmann, J. J., Kaushik, M., & Corzilius, B. (2017) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2017.06.002 · Cited by 544
Highly Efficient, Water‐Soluble Polarizing Agents for Dynamic Nuclear Polarization at High Frequency
Sauvée, C., Rosay, M., Casano, G., Aussenac, F., Weber, R. T., Ouari, O., & Tordo, P. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201304657 · Cited by 503
Beyond theT1Limit: Singlet Nuclear Spin States in Low Magnetic Fields
Carravetta, M., Johannessen, O. G., & Levitt, M. H. (2004) · Physical Review Letters · doi:10.1103/physrevlett.92.153003 · Cited by 384
Molecular architecture of fungal cell walls revealed by solid-state NMR
Kang, X., Kirui, A., Muszyński, A., Widanage, M. C. D., Chen, A., Azadi, P., Wang, P., Mentink-Vigier, F., & Wang, T. (2018) · Nature Communications · doi:10.1038/s41467-018-05199-0 · Cited by 356
Metadata
- Authors
- Hall, D. A., Maus, D. C., Gerfen, G. J., Inati, S. J., Becerra, L. R., Dahlquist, F. W., & Griffin, R. G.
- Venue
- Science
- Published
- 1997-05-09
- Volume
- 276
- Issue
- 5314
- Pages
- 930-932
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091113012
- Cited by
- 553
- References
- 0
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hall, D. A., Maus, D. C., Gerfen, G. J., Inati, S. J., Becerra, L. R., Dahlquist, F. W., & Griffin, R. G. (1997). Polarization-Enhanced NMR Spectroscopy of Biomolecules in Frozen Solution. Science. https://doi.org/10.1126/science.276.5314.930
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
