The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Sensitization to Morphine Induced by Viral-Mediated Gene Transfer
Abstract
Repeated administration of morphine sensitizes animals to the stimulant and rewarding properties of the drug. It also selectively increases expression of GluR1 (an AMPA glutamate receptor subunit) in the ventral tegmental area, a midbrain region implicated in morphine action. By viral-mediated gene transfer, a causal relation is shown between these behavioral and biochemical adaptations: Morphine's stimulant and rewarding properties are intensified after microinjections of a viral vector expressing GluR1 into the ventral tegmental area. These results confirm the importance of AMPA receptors in morphine action and demonstrate specific locomotor and motivational adaptations resulting from altered expression of a single localized gene product.
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Cites
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Cited by
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
The Glutamate Receptor Ion Channels
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NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
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Metadata
- Authors
- Carlezon, W. A., Boundy, V. A., Haile, C. N., Lane, S. B., Kalb, R. G., Neve, R. L., & Nestler, E. J.
- Venue
- Science
- Published
- 1997-08-08
- Volume
- 277
- Issue
- 5327
- Pages
- 812-815
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026721213
- Cited by
- 279
- References
- 29
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Carlezon, W. A., Boundy, V. A., Haile, C. N., Lane, S. B., Kalb, R. G., Neve, R. L., & Nestler, E. J. (1997). Sensitization to Morphine Induced by Viral-Mediated Gene Transfer. Science. https://doi.org/10.1126/science.277.5327.812
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
