The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development
Abstract
Signaling cascades triggered by receptor tyrosine kinases (RTKs) participate in diverse developmental processes. The active state of these signaling pathways was monitored by examination of the in situ distribution of the active, dual phosphorylated form of mitogen-activated protein kinase (ERK) with a specific monoclonal antibody. Detection of the active state of the Drosophila epidermal growth factor receptor (DER) pathway allowed the visualization of gradients and boundaries of receptor activation, assessment of the distribution of activating ligands, and analysis of interplay with the inhibitory ligand Argos. This in situ approach can be used to monitor other receptor-triggered pathways in a wide range of organisms.
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Cites
Schüpbach, T. (1987) · Cell · doi:10.1016/0092-8674(87)90546-0 · Cited by 367
Schweitzer, R., Shaharabany, M., Seger, R., & Shilo, B. Z. (1995) · Genes & Development · doi:10.1101/gad.9.12.1518 · Cited by 317
Self-citationPerkins, L. A., Johnson, M. R., Melnick, M. B., & Perrimon, N. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0285 · Cited by 114
Cited by
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
Corson, L. B., Yamanaka, Y., Lai, K.-M. V., & Rossant, J. (2003) · Development · doi:10.1242/dev.00669 · Cited by 390
Regenerative Growth in Drosophila Imaginal Discs Is Regulated by Wingless and Myc
Smith-Bolton, R. K., Worley, M. I., Kanda, H., & Hariharan, I. K. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.04.015 · Cited by 288
EGF signaling regulates the proliferation of intestinal stem cells in Drosophila
Biteau, B., & Jasper, H. (2011) · Development · doi:10.1242/dev.056671 · Cited by 306
MAP kinase in situ activation atlas during Drosophila embryogenesis
Gabay, L., Seger, R., & Shilo, B.-Z. (1997) · Development · doi:10.1242/dev.124.18.3535 · Cited by 304
Self-citationGenomic Regulatory Networks and Animal Development
Stathopoulos, A., & Levine, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.005 · Cited by 223
Metadata
- Authors
- Gabay, L., Seger, R., & Shilo, B.-Z.
- Venue
- Science
- Published
- 1997-08-22
- Volume
- 277
- Issue
- 5329
- Pages
- 1103-1106
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970180329
- Cited by
- 372
- References
- 3
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gabay, L., Seger, R., & Shilo, B.-Z. (1997). In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development. Science. https://doi.org/10.1126/science.277.5329.1103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
