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A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes
Abstract
Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone calreticulin, interact with the transporter associated with antigen processing (TAP) through a molecule called tapasin. The molecular cloning of tapasin revealed it to be a transmembrane glycoprotein encoded by an MHC-linked gene. It is a member of the immunoglobulin superfamily with a probable cytoplasmic endoplasmic reticulum retention signal. Up to four MHC class I–tapasin complexes were found to bind to each TAP molecule. Expression of tapasin in a negative mutant human cell line (220) restored class I–TAP association and normal class I cell surface expression. Tapasin expression also corrected the defective recognition of virus-infected 220 cells by class I–restricted cytotoxic T cells, establishing a critical functional role for tapasin in MHC class I–restricted antigen processing.
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Hammond, C., & Helenius, A. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.1.41 · Cited by 443
Cited by
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Rudd, P. M., Elliott, T., Cresswell, P., Wilson, I. A., & Dwek, R. A. (2001) · Science · doi:10.1126/science.291.5512.2370 · Cited by 1,588
Self-citationLeone, P., Shin, E.-C., Perosa, F., Vacca, A., Dammacco, F., & Racanelli, V. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt184 · Cited by 553
Optimization of the MHC Class I Peptide Cargo Is Dependent on Tapasin
Williams, A. P., Peh, C. A., Purcell, A. W., McCluskey, J., & Elliott, T. (2002) · Immunity · doi:10.1016/s1074-7613(02)00304-7 · Cited by 353
Antigen processing and presentation
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Metadata
- Authors
- Ortmann, B., Copeman, J., Lehner, P. J., Sadasivan, B., Herberg, J. A., Grandea, A. G., Riddell, S. R., Tampé, R., Spies, T., Trowsdale, J., & Cresswell, P.
- Venue
- Science
- Published
- 1997-08-29
- Volume
- 277
- Issue
- 5330
- Pages
- 1306-1309
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2147402069
- Cited by
- 525
- References
- 1
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Ortmann, B., Copeman, J., Lehner, P. J., Sadasivan, B., Herberg, J. A., Grandea, A. G., Riddell, S. R., Tampé, R., Spies, T., Trowsdale, J., & Cresswell, P. (1997). A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes. Science. https://doi.org/10.1126/science.277.5330.1306
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
