The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF
Abstract
Activation domains are functional modules that enable sequence-specific DNA binding proteins to stimulate transcription. The structural basis for the function of activation domains is poorly understood. A combination of nuclear magnetic resonance (NMR) and biochemical experiments revealed that the minimal acidic activation domain of the herpes simplex virus VP16 protein undergoes an induced transition from random coil to α helix upon binding to its target protein, hTAF II 31 (a human TFIID TATA box – binding protein-associated factor). Identification of the two hydrophobic residues that make nonpolar contacts suggests a general recognition motif of acidic activation domains for hTAF II 31.
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Cites
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Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.948 · Cited by 2,206
Self-citationMechanisms of transcription complex assembly
Pugh, B. F. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80002-0 · Cited by 87
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Radhakrishnan, I., Pérez-Alvarado, G. C., Parker, D., Dyson, H. J., Montminy, M. R., & Wright, P. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80463-8 · Cited by 728
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Freedman, D. A., Wu, L., & Levine, A. J. (1999) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/s000180050273 · Cited by 577
Self-citationCap-Dependent Translation Initiation in Eukaryotes Is Regulated by a Molecular Mimic of eIF4G
Marcotrigiano, J., Gingras, A.-C., Sonenberg, N., & Burley, S. K. (1999) · Molecular Cell · doi:10.1016/s1097-2765(01)80003-4 · Cited by 512
Metadata
- Authors
- Uesugi, M., Nyanguile, O., Lu, H., Levine, A. J., & Verdine, G. L.
- Venue
- Science
- Published
- 1997-08-29
- Volume
- 277
- Issue
- 5330
- Pages
- 1310-1313
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021825316
- Cited by
- 286
- References
- 2
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Uesugi, M., Nyanguile, O., Lu, H., Levine, A. J., & Verdine, G. L. (1997). Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF. Science. https://doi.org/10.1126/science.277.5330.1310
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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