Coupling of folding and binding for unstructured proteins
Abstract
There are now numerous examples of proteins that are unstructured or only partially structured under physiological conditions and yet are nevertheless functional. Such proteins are especially prevalent in eukaryotes. In many cases, intrinsically disordered proteins adopt folded structures upon binding to their biological targets. Many new examples of coupled folding and binding events have been reported recently, providing new insights into mechanisms of molecular recognition.
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Many IDPs/IDRs are capable of at least partial ordering upon interaction with specific partners.
“Many IDPs/IDRs are capable of at least partial ordering upon interaction with specific partners [7–18].”
From Intrinsically disordered proteins play diverse roles in cell signaling (2022) · cites this paper as [12]
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- Authors
- Dyson, H. J., & Wright, P. E.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Dyson, H.Jane
- Wright, Peter E
- Venue
- Current Opinion in Structural Biology
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 12
- Issue
- 1
- Pages
- 54-60
- ISSN
- 0959-440X (ISSN-L)
- OpenAlex
- W2052606462
- Cited by
- 1,327
- References
- 62
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 37 · 2023: 30 · 2022: 40 · 2021: 45 · 2020: 57 · 2019: 47 · 2018: 50 · 2017: 43 · 2016: 43 · 2015: 48 · 2014: 65 · 2013: 73 · 2012: 71
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Structural Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM57374, GM-36643, R01GM036643, R01GM057374)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 34909)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Keywords
- intrinsically disordered proteins, coupled folding and binding, protein folding, protein-ligand binding, molecular recognition, protein structure, eukaryotic proteins
- MeSH terms
- Animals, DNA-Binding Proteins, Eukaryotic Cells, Humans, Protein Binding, Signal Transduction, Zinc Fingers, Protein Folding
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