Cited by 1,327Protein Structure and DynamicsProtein Interaction Studies and Fluorescence AnalysisEnzyme Structure and Function

Coupling of folding and binding for unstructured proteins

Dyson, H.Jane, Wright, Peter E·2002·Current Opinion in Structural Biology

Abstract

There are now numerous examples of proteins that are unstructured or only partially structured under physiological conditions and yet are nevertheless functional. Such proteins are especially prevalent in eukaryotes. In many cases, intrinsically disordered proteins adopt folded structures upon binding to their biological targets. Many new examples of coupled folding and binding events have been reported recently, providing new insights into mechanisms of molecular recognition.

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Crossref · 10.1016/s0959-440x(02)00289-0

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Authors
Dyson, H. J., & Wright, P. E.
Affiliations
Scripps Research Institute (US)
Corresponding author
  • Dyson, H.Jane
  • Wright, Peter E
Venue
Current Opinion in Structural Biology
Publisher
Elsevier BV
Published
2002-02
Volume
12
Issue
1
Pages
54-60
ISSN
0959-440X (ISSN-L)
OpenAlex
W2052606462
Cited by
1,327
References
62
Citations by year
2026: 16 · 2025: 16 · 2024: 37 · 2023: 30 · 2022: 40 · 2021: 45 · 2020: 57 · 2019: 47 · 2018: 50 · 2017: 43 · 2016: 43 · 2015: 48 · 2014: 65 · 2013: 73 · 2012: 71
FWCI
6.17
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Structural Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of General Medical Sciences (GM57374, GM-36643, R01GM036643, R01GM057374)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 34909)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
  • Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
Keywords
intrinsically disordered proteins, coupled folding and binding, protein folding, protein-ligand binding, molecular recognition, protein structure, eukaryotic proteins
MeSH terms
Animals, DNA-Binding Proteins, Eukaryotic Cells, Humans, Protein Binding, Signal Transduction, Zinc Fingers, Protein Folding

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