The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase
Abstract
Arrest of the cell cycle at the G 2 checkpoint, induced by DNA damage, requires inhibitory phosphorylation of the kinase Cdc2 in both fission yeast and human cells. The kinase Wee1 and the phosphatase Cdc25, which regulate Cdc2 phosphorylation, were evaluated as targets of Chk1, a kinase essential for the checkpoint. Fission yeast cdc2-3w Δcdc25 cells, which express activated Cdc2 and lack Cdc25, were responsive to Wee1 but insensitive to Chk1 and irradiation. Expression of large amounts of Chk1 produced the same phenotype as did loss of the cdc25 gene in cdc2-3w cells. Cdc25 associated with Chk1 in vivo and was phosphorylated when copurified in Chk1 complexes. These findings identify Cdc25, but not Wee1, as a target of the DNA damage checkpoint.
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Cites
[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
Moreno, S., Klar, A., & Nurse, P. (1991) · Methods in Enzymology · doi:10.1016/0076-6879(91)94059-l · Cited by 3,620
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Metadata
- Authors
- Furnari, B., Rhind, N., & Russell, P.
- Venue
- Science
- Published
- 1997-09-05
- Volume
- 277
- Issue
- 5331
- Pages
- 1495-1497
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969308341
- Cited by
- 539
- References
- 1
- FWCI
- 20.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Furnari, B., Rhind, N., & Russell, P. (1997). Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase. Science. https://doi.org/10.1126/science.277.5331.1495
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
