The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 WAF1
Abstract
DNA–(cytosine-5) methyltransferase (MCMT) methylates newly replicated mammalian DNA, but the factors regulating this activity are unknown. Here, MCMT is shown to bind proliferating cell nuclear antigen (PCNA), an auxiliary factor for DNA replication and repair. Binding of PCNA requires amino acids 163 to 174 of MCMT, occurs in intact cells at foci of newly replicated DNA, and does not alter MCMT activity. A peptide derived from the cell cycle regulator p21 WAF1 can disrupt the MCMT-PCNA interaction, which suggests that p21 WAF1 may regulate methylation by blocking access of MCMT to PCNA. MCMT and p21 WAF1 may be linked in a regulatory pathway, because the extents of their expression are inversely related in both SV40-transformed and nontransformed cells.
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Citations
Cites
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/369574a0 · Cited by 1,655
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
Lei, H., Oh, S. P., Okano, M., Jüttermann, R., Goss, K. A., Jaenisch, R., & Li, E. (1996) · Development · doi:10.1242/dev.122.10.3195 · Cited by 816
Cited by
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
PCNA, the Maestro of the Replication Fork
Moldovan, G.-L., Pfander, B., & Jentsch, S. (2007) · Cell · doi:10.1016/j.cell.2007.05.003 · Cited by 1,796
UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells
Bostick, M., Kim, J. K., Estève, P.-O., Clark, A., Pradhan, S., & Jacobsen, S. E. (2007) · Science · doi:10.1126/science.1147939 · Cited by 1,455
Robertson, K. D., Ait-Si-Ali, S., Yokochi, T., Wade, P. A., Jones, P. L., & Wolffe, A. P. (2000) · Nature Genetics · doi:10.1038/77124 · Cited by 942
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., et al. (2001) · Nature Genetics · doi:10.1038/83730 · Cited by 694
Metadata
- Authors
- Chuang, L. S.-H., Ian, H.-I., Koh, T.-W., Ng, H.-H., Xu, G., & Li, B. F. L.
- Venue
- Science
- Published
- 1997-09-26
- Volume
- 277
- Issue
- 5334
- Pages
- 1996-2000
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055171335
- Cited by
- 902
- References
- 2
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chuang, L. S.-H., Ian, H.-I., Koh, T.-W., Ng, H.-H., Xu, G., & Li, B. F. L. (1997). Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 WAF1. Science. https://doi.org/10.1126/science.277.5334.1996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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