The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells
Abstract
Epigenetic inheritance in mammals relies in part on robust propagation of DNA methylation patterns throughout development. We show that the protein UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1), also known as NP95 in mouse and ICBP90 in human, is required for maintaining DNA methylation. UHRF1 colocalizes with the maintenance DNA methyltransferase protein DNMT1 throughout S phase. UHRF1 appears to tether DNMT1 to chromatin through its direct interaction with DNMT1. Furthermore UHRF1 contains a methyl DNA binding domain, the SRA (SET and RING associated) domain, that shows strong preferential binding to hemimethylated CG sites, the physiological substrate for DNMT1. These data suggest that UHRF1 may help recruit DNMT1 to hemimethylated DNA to facilitate faithful maintenance of DNA methylation.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
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A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
Leonhardt, H., Page, A. W., Weier, H.-U., & Bestor, T. H. (1992) · Cell · doi:10.1016/0092-8674(92)90561-p · Cited by 1,055
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Bestor, T., Laudano, A., Mattaliano, R., & Ingram, V. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90122-2 · Cited by 913
Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 WAF1
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Epigenetic inheritance in plants
Henderson, I. R., & Jacobsen, S. E. (2007) · Nature · doi:10.1038/nature05917 · Cited by 835
Self-citationRecombinant Human DNA (Cytosine-5) Methyltransferase
Pradhan, S., Bacolla, A., Wells, R. D., & Roberts, R. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33002 · Cited by 651
Self-citationActivation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.
Bestor, T. H. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05326.x · Cited by 461
The SRA Methyl-Cytosine-Binding Domain Links DNA and Histone Methylation
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Self-citationICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain
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Cited by
DNA methylation and its basic function
Moore, L. D., Le, T., & Fan, G. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.112 · Cited by 4,906
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
Linking DNA methylation and histone modification: patterns and paradigms
Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267
TET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661
Conservation and divergence of methylation patterning in plants and animals
Feng, S., Cokus, S. J., Zhang, X., Chen, P.-Y., Bostick, M., Goll, M. G., Hetzel, J., Jain, J., Strauss, S. H., Halpern, M. E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002720107 · Cited by 1,285
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Metadata
- Authors
- Bostick, M., Kim, J. K., Estève, P.-O., Clark, A., Pradhan, S., & Jacobsen, S. E.
- Venue
- Science
- Published
- 2007-09-21
- Volume
- 317
- Issue
- 5845
- Pages
- 1760-1764
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142745453
- Cited by
- 1,455
- References
- 26
- FWCI
- 18.20
- Type
- journal article
- Language
- en
- Open access
- closed
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