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Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations
Abstract
Immunotherapy of mice with preexisting cancers with heat shock protein preparations derived from autologous cancer resulted in retarded progression of the primary cancer, a reduced metastatic load, and prolongation of life-span. Treatment with heat shock protein preparations derived from cancers other than the autologous cancer did not provide significant protection. Spontaneous cancers (lung cancer and melanoma), chemically induced cancers (fibrosarcoma and colon carcinoma), and an ultraviolet radiation-induced spindle cell carcinoma were tested, and the results support the efficacy of autologous cancer–derived heat shock protein–peptide complexes in immunotherapy of cancers without the need to identify specific tumor antigenic epitopes.
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Citations
Cited by
Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
Wolfers, J., Lozier, A., Raposo, G., Regnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,640
Roles of heat-shock proteins in innate and adaptive immunity.
Srivastava, P. (2002) · Nature reviews. Immunology · doi:10.1038/nri749 · Cited by 1,069
Self-citationRole of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death
Jolly, C. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.19.1564 · Cited by 1,048
A fresh look at tumor immunosurveillance and immunotherapy
Smyth, M. J., Godfrey, D. I., & Trapani, J. A. (2001) · Nature Immunology · doi:10.1038/86297 · Cited by 745
Metadata
- Authors
- Tamura, Y., Peng, P., Liu, K., Daou, M., & Srivastava, P. K.
- Venue
- Science
- Published
- 1997-10-03
- Volume
- 278
- Issue
- 5335
- Pages
- 117-120
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080335579
- Cited by
- 680
- References
- 0
- FWCI
- 15.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tamura, Y., Peng, P., Liu, K., Daou, M., & Srivastava, P. K. (1997). Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations. Science. https://doi.org/10.1126/science.278.5335.117
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
