Cited by 1,069Heat shock proteins researchImmunotherapy and Immune ResponsesImmune Response and Inflammation

Roles of heat-shock proteins in innate and adaptive immunity.

Srivastava, Pramod·2002·Nature reviews. Immunology

Abstract

Heat-shock proteins (HSPs) are the most abundant and ubiquitous soluble intracellular proteins. In single-cell organisms, invertebrates and vertebrates, they perform a multitude of housekeeping functions that are essential for cellular survival. In higher vertebrates, their ability to interact with a wide range of proteins and peptides--a property that is shared by major histocompatibility complex molecules--has made the HSPs uniquely suited to an important role in organismal survival by their participation in innate and adaptive immune responses. The immunological properties of HSPs enable them to be used in new immunotherapies of cancers and infections.

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Crossref · 10.1038/nri749

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  • Heat-shock proteins are immunodominant antigens for the recognition of many pathogens and play a central role in mediating both innate and adaptive immune responses.

    “Consistent with this thinking, heat-shock proteins are immunodominant antigens for the recognition of many pathogens and play a central role in mediating both innate and adaptive immune responses [54],[55].”

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Authors
Srivastava, P.
Affiliations
University of Connecticut (US)
Corresponding author
Srivastava, Pramod
Venue
Nature reviews. Immunology
Published
2002-03
Volume
2
Issue
3
Pages
185-194
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2054626405
Cited by
1,069
References
97
Citations by year
2026: 17 · 2025: 32 · 2024: 23 · 2023: 34 · 2022: 32 · 2021: 38 · 2020: 46 · 2019: 49 · 2018: 42 · 2017: 35 · 2016: 49 · 2015: 60 · 2014: 43 · 2013: 50 · 2012: 40
FWCI
4.23
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
heat shock proteins, innate immunity, adaptive immunity, immunotherapeutics, cancer immunotherapy
MeSH terms
Animals, Heat-Shock Proteins, Humans, Immunity, Innate, Immunotherapy, Infections, Neoplasms, T-Lymphocytes, Cytotoxic, Vaccination, Antigen Presentation

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