Roles of heat-shock proteins in innate and adaptive immunity.
Abstract
Heat-shock proteins (HSPs) are the most abundant and ubiquitous soluble intracellular proteins. In single-cell organisms, invertebrates and vertebrates, they perform a multitude of housekeeping functions that are essential for cellular survival. In higher vertebrates, their ability to interact with a wide range of proteins and peptides--a property that is shared by major histocompatibility complex molecules--has made the HSPs uniquely suited to an important role in organismal survival by their participation in innate and adaptive immune responses. The immunological properties of HSPs enable them to be used in new immunotherapies of cancers and infections.
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Heat-shock proteins are immunodominant antigens for the recognition of many pathogens and play a central role in mediating both innate and adaptive immune responses.
“Consistent with this thinking, heat-shock proteins are immunodominant antigens for the recognition of many pathogens and play a central role in mediating both innate and adaptive immune responses [54],[55].”
From Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin (2009) · cites this paper as [54]
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- Authors
- Srivastava, P.
- Affiliations
- University of Connecticut (US)
- Corresponding author
- Srivastava, Pramod
- ORCID
- Srivastava, Pramod
- Venue
- Nature reviews. Immunology
- Published
- 2002-03
- Volume
- 2
- Issue
- 3
- Pages
- 185-194
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2054626405
- Cited by
- 1,069
- References
- 97
- Citations by year
- 2026: 17 · 2025: 32 · 2024: 23 · 2023: 34 · 2022: 32 · 2021: 38 · 2020: 46 · 2019: 49 · 2018: 42 · 2017: 35 · 2016: 49 · 2015: 60 · 2014: 43 · 2013: 50 · 2012: 40
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- heat shock proteins, innate immunity, adaptive immunity, immunotherapeutics, cancer immunotherapy
- MeSH terms
- Animals, Heat-Shock Proteins, Humans, Immunity, Innate, Immunotherapy, Infections, Neoplasms, T-Lymphocytes, Cytotoxic, Vaccination, Antigen Presentation
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