The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Counteraction by MutT Protein of Transcriptional Errors Caused by Oxidative Damage
Abstract
Oxidized guanine (8-oxo-7,8-dihydroguanine; 8-oxo-G) is a potent mutagen because of its ambiguous pairing with cytosine and adenine. The Escherichia coli MutT protein specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-rGTP), which are otherwise incorporated in DNA and RNA opposite template A. In vivo, this cleaning of the nucleotide pools decreases both DNA replication and transcription errors. The effect of mutT mutation on transcription fidelity was shown to depend on oxidative metabolism. Such control of transcriptional fidelity by the ubiquitous MutT function has implications for evolution of RNA-based life, phenotypic expression, adaptive mutagenesis, and functional maintenance of nondividing cells.
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Experiments in molecular genetics
Miller, J. H. (1972) · Medical Entomology and Zoology · Cited by 27,157
Cairns, J., Overbaugh, J., & Miller, S. (1988) · Nature · doi:10.1038/335142a0 · Cited by 1,025
THE MAINTENANCE OF THE ACCURACY OF PROTEIN SYNTHESIS AND ITS RELEVANCE TO AGEING
Orgel, L. E. (1963) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.49.4.517 · Cited by 969
MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis
Maki, H., & Sekiguchi, M. (1992) · Nature · doi:10.1038/355273a0 · Cited by 891
Self-citationSakumi, K., Furuichi, M., Tsuzuki, T., Kakuma, T., Kawabata, S., Maki, H., & Sekiguchi, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49494-5 · Cited by 433
Self-citationTajiri, T., Maki, H., & Sekiguchi, M. (1995) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(94)00062-b · Cited by 335
Self-citationMo, J. Y., Maki, H., & Sekiguchi, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.11021 · Cited by 312
Self-citationSPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and Repair
Miller, J. H. (1996) · Annual Review of Microbiology · doi:10.1146/annurev.micro.50.1.625 · Cited by 253
A Factor (or Mutator Gene) Influencing Mutation Rates in Escherichia Coli
Treffers, H. P., Spinelli, V., & Belser, N. O. (1954) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.40.11.1064 · Cited by 230
Cited by
Oxidative DNA damage and disease: induction, repair and significance
Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372
Oxidative Stress Resistance in Deinococcus radiodurans
Slade, D., & Radman, M. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00015-10 · Cited by 761
Self-citationStress-Induced Mutagenesis in Bacteria
Bjedov, I., Tenaillon, O., Gérard, B., Souza, V., Denamur, E., Radman, M., Taddei, F., & Matic, I. (2003) · Science · doi:10.1126/science.1082240 · Cited by 587
Self-citationMutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions
Wang, D., Kreutzer, D. A., & Essigmann, J. M. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00066-9 · Cited by 464
Evolution of mutation rates in bacteria
Denamur, E., & Matic, I. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05150.x · Cited by 401
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Metadata
- Authors
- Taddei, F., Hayakawa, H., Bouton, M.-F., Cirinesi, A.-M., Matic, I., Sekiguchi, M., & Radman, M.
- Venue
- Science
- Published
- 1997-10-03
- Volume
- 278
- Issue
- 5335
- Pages
- 128-130
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077007523
- Cited by
- 278
- References
- 23
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taddei, F., Hayakawa, H., Bouton, M.-F., Cirinesi, A.-M., Matic, I., Sekiguchi, M., & Radman, M. (1997). Counteraction by MutT Protein of Transcriptional Errors Caused by Oxidative Damage. Science. https://doi.org/10.1126/science.278.5335.128
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
