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Cited by 563

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

DeGrendele, Heather C., Estess, Pila, Siegelman, Mark H.·1997·Science

Abstract

Leukocytes extravasate from the blood into inflammatory sites through complementary ligand interactions between leukocytes and endothelial cells. Activation of T cells increases their binding to hyaluronate (HA) and enables CD44-mediated primary adhesion (rolling). This rolling could be induced in vivo in murine V β 8 + T cells in response to specific superantigen stimulation; it was initially found in lymph nodes, then in peripheral blood, and finally within the peritoneum, the original inflamed site. The migration of V β 8 + cells into the peritoneal cavity was dependent on CD44 and HA, as shown by inhibition studies. Thus, CD44-HA interactions can target lymphocytes to specific extralymphoid effector sites.

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Crossref · 10.1126/science.278.5338.672

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Metadata

Authors
DeGrendele, H. C., Estess, P., & Siegelman, M. H.
Venue
Science
Published
1997-10-24
Volume
278
Issue
5338
Pages
672-675
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2062264071
Cited by
563
References
1
FWCI
9.55
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site. https://app.cochat.ai/papers/10.1126/science.278.5338.672
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DeGrendele, H. C., Estess, P., & Siegelman, M. H. (1997). Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site. Science. https://doi.org/10.1126/science.278.5338.672

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.