The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Resolution of Lung Inflammation by CD44
Abstract
Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation. CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury, characterized by impaired clearance of apoptotic neutrophils, persistent accumulation of hyaluronan fragments at the site of tissue injury, and impaired activation of transforming growth factor–β 1 . This phenotype was partially reversed by reconstitution with CD44 + cells, thus demonstrating a critical role for this receptor in resolving lung inflammation.
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Self-citationCD44 is the principal cell surface receptor for hyaluronate
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Self-citationHaslett, C., Guthrie, L. A., Kopaniak, M. M., Johnston, R. B., & Henson, P. M. (1985) · PubMed Central · Cited by 779
Self-citationRequirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site
DeGrendele, H. C., Estess, P., & Siegelman, M. H. (1997) · Science · doi:10.1126/science.278.5338.672 · Cited by 563
The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.
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Cited by
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429
CD44: From adhesion molecules to signalling regulators
Ponta, H., Sherman, L., & Herrlich, P. A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1004 · Cited by 2,386
Hyaluronan: from extracellular glue to pericellular cue
Toole, B. P. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1391 · Cited by 2,125
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G. D., Mascarenhas, M. M., Garg, H. G., Quinn, D. A., et al. (2005) · Nature Medicine · doi:10.1038/nm1315 · Cited by 1,401
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Metadata
- Authors
- Teder, P., Vandivier, R. W., Jiang, D., Liang, J., Cohn, L., Puré, E., Henson, P. M., & Noble, P. W.
- Venue
- Science
- Published
- 2002-04-05
- Volume
- 296
- Issue
- 5565
- Pages
- 155-158
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964179595
- Cited by
- 677
- References
- 21
- FWCI
- 14.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Teder, P., Vandivier, R. W., Jiang, D., Liang, J., Cohn, L., Puré, E., Henson, P. M., & Noble, P. W. (2002). Resolution of Lung Inflammation by CD44. Science. https://doi.org/10.1126/science.1069659
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
