The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Structural Plasticity in a Remodeled Protein-Protein Interface
Abstract
Remodeling of the interface between human growth hormone (hGH) and the extracellular domain of its receptor was studied by deleting a critical tryptophan residue (at position 104) in the receptor, creating a large cavity, and selecting a pentamutant of hGH by phage display that fills the cavity and largely restores binding affinity. A 2.1 Å resolution x-ray structure of the mutant complex showed that the receptor cavity was filled by selected hydrophobic mutations of hGH. Large structural rearrangements occurred in the interface at sites that were distant from the mutations. Such plasticity may be a means for protein-protein interfaces to adapt to mutations as they coevolve.
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Citations
Cites
Principles of protein-protein interactions
Jones, S., & Thornton, J. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.13 · Cited by 2,684
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Anatomy of hot spots in protein interfaces
Bogan, A. A., & Thorn, K. S. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1843 · Cited by 1,988
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Arkin, M. R., & Wells, J. A. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1343 · Cited by 1,705
Self-citationEvolutionarily Conserved Pathways of Energetic Connectivity in Protein Families
Lockless, S. W., & Ranganathan, R. (1999) · Science · doi:10.1126/science.286.5438.295 · Cited by 1,303
A simple physical model for binding energy hot spots in protein–protein complexes
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Metadata
- Authors
- Atwell, S., Ultsch, M., De Vos, A. M., & Wells, J. A.
- Venue
- Science
- Published
- 1997-11-07
- Volume
- 278
- Issue
- 5340
- Pages
- 1125-1128
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086518221
- Cited by
- 180
- References
- 1
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Atwell, S., Ultsch, M., De Vos, A. M., & Wells, J. A. (1997). Structural Plasticity in a Remodeled Protein-Protein Interface. Science. https://doi.org/10.1126/science.278.5340.1125
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
