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Mechanism of Transcription Through the Nucleosome by Eukaryotic RNA Polymerase
Abstract
Nucleosomes, the nucleohistone subunits of chromatin, are present on transcribed eukaryotic genes but do not prevent transcription. It is shown here that the large yeast RNA polymerase III transcribes through a single nucleosome. This takes place through a direct internal nucleosome transfer in which histones never leave the DNA template. During this process, the polymerase pauses with a pronounced periodicity of 10 to 11 base pairs, which is consistent with restricted rotation in the DNA loop formed during transfer. Transcription through nucleosomes by the eukaryotic enzyme and by much smaller prokaryotic RNA polymerases thus shares many features, reflecting an important property of nucleosomes.
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Citations
Cited by
STRUCTURE, DYNAMICS, AND FUNCTION OF CHROMATIN IN VITRO
Widom, J. (1998) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.27.1.285 · Cited by 284
Chromatin and Transcription in Yeast
Rando, O. J., & Winston, F. (2012) · Genetics · doi:10.1534/genetics.111.132266 · Cited by 269
Li, Q., Imhof, A., Collingwood, T. N., Urnov, F. D., & Wolffe, A. P. (1999) · The EMBO Journal · doi:10.1093/emboj/18.20.5634 · Cited by 78
Structural dynamics of nucleosomes at single-molecule resolution
Choy, J. S., & Lee, T.-H. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.06.006 · Cited by 27
Metadata
- Authors
- Studitsky, V. M., Kassavetis, G. A., Geiduschek, E. P., & Felsenfeld, G.
- Venue
- Science
- Published
- 1997-12-12
- Volume
- 278
- Issue
- 5345
- Pages
- 1960-1963
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088778716
- Cited by
- 202
- References
- 0
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Studitsky, V. M., Kassavetis, G. A., Geiduschek, E. P., & Felsenfeld, G. (1997). Mechanism of Transcription Through the Nucleosome by Eukaryotic RNA Polymerase. Science. https://doi.org/10.1126/science.278.5345.1960
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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