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Influence of Interior Packing and Hydrophobicity on the Stability of a Protein
Abstract
Protein interiors contain many tightly packed apolar atoms in a nearly crystalline state. Both shielding of apolar atoms from solvent and efficient interior packing arrangements affect protein stability, but their relative importance is unclear. To separate these effects, the stabilities of wild-type and mutant gene V proteins from bacteriophage fl were studied by measuring resistance to denaturation. The effects of subtle interior packing changes, both separate from and combined with changes in buried side chain hydrophobicity, were measured. For the interior apolar-to-apolar substitutions studied, the two effects were of the same magnitude and alteration of packing without accompanying hydrophobicity changes substantially destabilized the protein.
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Citations
Cited by
A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure
Bowie, J. U., Lüthy, R., & Eisenberg, D. (1991) · Science · doi:10.1126/science.1853201 · Cited by 2,851
Relative helix-forming tendencies of nonpolar amino acids
Padmanabhan, S., Marqusee, S., Ridgeway, T., Laue, T. M., & Baldwin, R. L. (1990) · Nature · doi:10.1038/344268a0 · Cited by 462
De novo design of the hydrophobic cores of proteins
Desjarlais, J. R., & Handel, T. M. (1995) · Protein Science · doi:10.1002/pro.5560041006 · Cited by 306
Exterkate, F. A. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.5.2021-2028.2000 · Cited by 18
Metadata
- Authors
- Sandberg, W. S., & Terwilliger, T. C.
- Venue
- Science
- Published
- 1989-07-07
- Volume
- 245
- Issue
- 4913
- Pages
- 54-57
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081670113
- Cited by
- 171
- References
- 0
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Influence of Interior Packing and Hydrophobicity on the Stability of a Protein. https://app.cochat.ai/papers/10.1126/science.2787053
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- Sandberg, W. S., & Terwilliger, T. C. (1989). Influence of Interior Packing and Hydrophobicity on the Stability of a Protein. Science. https://doi.org/10.1126/science.2787053
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
