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Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice
Abstract
When rodents are infected with the nematode Nippostrongylus brasiliensis , large numbers of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil production in vivo and that IgE and eosinophil production are regulated by different cytokines produced by the T H 2 subset of CD4-expressing T cells.
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Citations
Cited by
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526
“Thus, activated T cells may affect hematopoietic progenitors both directly through the production of IL-3 (23- 25), IL-4 (26-28), IL-5 (29-31), and GM-CSF (32, 33), as well as indirectly through the secretion of hlL-17.”
Foster, P. S., Hogan, S. P., Ramsay, A. J., Matthaei, K. I., & Young, I. G. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.1.195 · Cited by 1,370
Disruption of the murine IL-4 gene blocks Th2 cytokine responses
Kopf, M., Gros, G. L., Bachmann, M., Lamers, M. C., Bluethmann, H., & Köhler, G. (1993) · Nature · doi:10.1038/362245a0 · Cited by 1,203
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Deplancke, B., & Gaskins, H. R. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1131s · Cited by 1,012
Eosinophils: Biological Properties and Role in Health and Disease
HOGAN, S. P., ROSENBERG, H. F., MOQBEL, R., PHIPPS, S., FOSTER, P. S., LACY, P., KAY, A. B., & ROTHENBERG, M. E. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.02958.x · Cited by 834
Metadata
- Authors
- Coffman, R. L., Seymour, B. W. P., Hudak, S., Jackson, J., & Rennick, D.
- Venue
- Science
- Published
- 1989-07-21
- Volume
- 245
- Issue
- 4915
- Pages
- 308-310
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072490043
- Cited by
- 633
- References
- 0
- FWCI
- 34.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice. https://app.cochat.ai/papers/10.1126/science.2787531
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- Coffman, R. L., Seymour, B. W. P., Hudak, S., Jackson, J., & Rennick, D. (1989). Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice. Science. https://doi.org/10.1126/science.2787531
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