Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Open accessAbstract
The gastrointestinal epithelium is covered by a protective mucus gel composed predominantly of mucin glycoproteins that are synthesized and secreted by goblet cells. Changes in goblet cell functions and in the chemical composition of intestinal mucus are detected in response to a broad range of luminal insults, including alterations of the normal microbiota. However, the regulatory networks that mediate goblet cell responses to intestinal insults are poorly defined. The present review summarizes the results of developmental, gnotobiotic, and in vitro studies that showed alterations in mucin gene expression, mucus composition, or mucus secretion in response to intestinal microbes or host-derived inflammatory mediators. The dynamic nature of the mucus layer is shown. Available data indicate that intestinal microbes may affect goblet cell dynamics and the mucus layer directly via the local release of bioactive factors or indirectly via activation of host immune cells. A precise definition of the regulatory networks that interface with goblet cells may have broad biomedical applications because mucus alterations appear to characterize most diseases of mucosal tissues.
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Reintroduction of microbes via conventionalization elevates intestinal mucin levels.
“Previous studies have reported that the reintroduction of microbes via conventionalization elevates mucin levels in the intestine.51,52”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [52]
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“Also of interest is evidence from humans that resident mucolytic bacteria may differ among individuals according to the specific carbohydrate composition of intestinal mucins (eg, terminal sugars or branching patterns), which appears to vary by genetic background (117, 118).”
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- Authors
- Deplancke, B., & Gaskins, H. R.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 73
- Issue
- 6
- Pages
- 1131S-1141S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2148908418
- Cited by
- 1,012
- References
- 1
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 37 · 2023: 47 · 2022: 78 · 2021: 53 · 2020: 75 · 2019: 57 · 2018: 57 · 2017: 45 · 2016: 38 · 2015: 45 · 2014: 60 · 2013: 60 · 2012: 40
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- goblet cells, intestinal mucus layer, mucin glycoproteins, gut microbiota, innate immunity, mucin gene expression, mucus secretion, inflammatory mediators, gnotobiotic models, host-microbe interactions, gastrointestinal epithelium, mucosal disease
- MeSH terms
- Animals, Cell Line, Humans, Intestinal Mucosa, Mucins, Mucus, Goblet Cells, Sialomucins, Mucin-2
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