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Catalytic Galactose Oxidase Models: Biomimetic Cu(II)-Phenoxyl-Radical Reactivity
Abstract
Biomimetic functional models of the mononuclear copper enzyme galactose oxidase are presented that catalytically oxidize benzylic and allylic alcohols to aldehydes with O 2 under mild conditions. The mechanistic fidelity between the models and the natural system is pronounced. Modest structural mimicry proves sufficient to transfer an unusual ligand-based radical mechanism, previously unprecedented outside the protein matrix, to a simple chemical system.
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Citations
Cited by
Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C.-R., Schumacker, P. T., Licht, J. D., Perlman, H., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.020 · Cited by 1,338
Mori, K., Hara, T., Mizugaki, T., Ebitani, K., & Kaneda, K. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0488683 · Cited by 939
Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2003638 · Cited by 315
Metadata
- Authors
- Wang, Y., DuBois, J. L., Hedman, B., Hodgson, K. O., & Stack, T. D. P.
- Venue
- Science
- Published
- 1998-01-23
- Volume
- 279
- Issue
- 5350
- Pages
- 537-540
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992749453
- Cited by
- 476
- References
- 0
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Catalytic Galactose Oxidase Models: Biomimetic Cu(II)-Phenoxyl-Radical Reactivity. https://app.cochat.ai/papers/10.1126/science.279.5350.537
- The paper
- Wang, Y., DuBois, J. L., Hedman, B., Hodgson, K. O., & Stack, T. D. P. (1998). Catalytic Galactose Oxidase Models: Biomimetic Cu(II)-Phenoxyl-Radical Reactivity. Science. https://doi.org/10.1126/science.279.5350.537
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.