Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development
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Skin development requires reactive oxygen species generated by mitochondria in keratinocytes.
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An increase in ROS, as encountered in spaceflight, triggers adult stem cell differentiation and rapidly switches to mitochondrial OXPHOS.
“An increase in ROS, as encountered in spaceflight, triggers adult stem cells differentiation, and rapidly switches to mitochondrial OXPHOS (Hamanaka et al., 2013; Ito and Suda, 2014).”
From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Hamanaka et al., 2013
The Introduction reports that mitochondrial ROS are required for differentiation of human bone marrow–derived mesenchymal stem cells into adipocytes, and the Results show that ROS support keratinocyte differentiation. The paper does not establish that spaceflight-associated ROS trigger adult stem-cell differentiation or cause a rapid switch to mitochondrial OXPHOS. The indexed passages provide section labels but no page numbers. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIntracellular ROS enhances fibroblasts, endothelial cells, and hair follicle cell proliferation.
“Intracellular ROS enhances fibroblasts, endothelial cells, and hair follicles cell proliferation (Day and Suzuki, 2006; Hamanaka et al., 2013).”
From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Hamanaka et al., 2013
The Introduction (page unavailable) says ROS participate in pathways regulating cellular proliferation, and the Results link mitochondrial ROS to hair follicle growth. But the paper does not establish that ROS enhance proliferation of fibroblasts, endothelial cells, or hair follicle cells specifically. Its Results instead report increased proliferation of epidermal basal keratinocytes when mitochondrial function and ROS were reduced. (LLM, conf=0.86)
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- Authors
- Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M., & Chandel, N. S.
- Affiliations
- Northwestern University (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Chandel, Navdeep S.
- ORCID
- Venue
- Science Signaling
- Published
- 2013-02-05
- Volume
- 6
- Issue
- 261
- Pages
- ra8-ra8
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC4017376
- OpenAlex
- W2142920152
- Cited by
- 315
- References
- 56
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 19 · 2023: 24 · 2022: 22 · 2021: 24 · 2020: 31 · 2019: 20 · 2018: 32 · 2017: 28 · 2016: 21 · 2015: 31 · 2014: 19 · 2013: 11
- FWCI
- 33.26
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r21ar061174-02)
- National Heart, Lung, and Blood Institute (F32HL099007)
- National Eye Institute (EY019463, R21EY017536, EY 06769, R01EY006769, F32EY006769, R01EY019463, EY017536)
- National Cancer Institute (R01CA157996)
- National Institute of General Medical Sciences (R01GM076561)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR057216, 5R21AR061174-02, R01AR062110, R21 AR061174, P30AR057216)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial reactive oxygen species, epidermal differentiation, hair follicle development, keratinocytes, TFAM, Notch signaling, β-catenin signaling, hydrogen peroxide, antioxidants, electron transport chain, tissue morphogenesis
- MeSH terms
- Epidermal Cells, Animals, Calcium Chloride, Cell Differentiation, Cells, Cultured, DNA-Binding Proteins, Epidermis, Female, High Mobility Group Proteins, Humans, Hydrogen Peroxide, Male, Mice, Transgenic, Mitochondria, Time Factors, Blotting, Western, Signal Transduction, Keratinocytes, Oxidants, Reactive Oxygen Species, Mice, Knockout, Hair Follicle, Reverse Transcriptase Polymerase Chain Reaction, beta Catenin, Mice, Receptors, Notch
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