The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expansion and Length-Dependent Fragility of CTG Repeats in Yeast
Abstract
Expansion of DNA trinucleotide repeats (TNRs) is the causative mutation in a growing number of human genetic diseases. Large expansions of a CTG tract were obtained and shown by genetic and physical assays to be length-dependent sites of chromosome breakage in Saccharomyces cerevisiae . Deletion of RAD27 , which encodes a nuclease involved in Okazaki fragment processing, caused length-dependent destabilization of CTG tracts and a substantial increase in expansion frequency. The genetic assay described here can be used to evaluate other factors that induce TNR expansion or chromosome fragility in humans.
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Citations
Cites
The distribution of the numbers of mutants in bacterial populations
Lea, D. E., & Coulson, C. A. (1949) · Journal of Genetics · doi:10.1007/bf02986080 · Cited by 1,450
Cited by
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120
Lindahl, T., & Wood, R. D. (1999) · Science · doi:10.1126/science.286.5446.1897 · Cited by 1,494
Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003
Expandable DNA repeats and human disease
Mirkin, S. M. (2007) · Nature · doi:10.1038/nature05977 · Cited by 934
Adams, S. R., Campbell, R. E., Gross, L. A., Martin, B. R., Walkup, G. K., Yao, Y., Llopis, J., & Tsien, R. Y. (2002) · Journal of the American Chemical Society · doi:10.1021/ja017687n · Cited by 927
Metadata
- Authors
- Freudenreich, C. H., Kantrow, S. M., & Zakian, V. A.
- Venue
- Science
- Published
- 1998-02-06
- Volume
- 279
- Issue
- 5352
- Pages
- 853-856
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069157381
- Cited by
- 402
- References
- 1
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Freudenreich, C. H., Kantrow, S. M., & Zakian, V. A. (1998). Expansion and Length-Dependent Fragility of CTG Repeats in Yeast. Science. https://doi.org/10.1126/science.279.5352.853
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
