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Chemical Dynamics in Proteins: The Photoisomerization of Retinal in Bacteriorhodopsin
Abstract
Chemical dynamics in proteins are discussed, with bacteriorhodopsin serving as a model system. Ultrafast time-resolved methods used to probe the chemical dynamics of retinal photoisomerization in bacteriorhodopsin are discussed, along with future prospects for ultrafast time-resolved crystallography. The photoisomerization of retinal in bacteriorhodopsin is far more selective and efficient than in solution, the origins of which are discussed in the context of a three-state model for the photoisomerization reaction coordinate. The chemical dynamics are complex, with the excited-state relaxation exhibiting a multiexponential decay with well-defined rate constants. Possible origins for the two major components are also discussed.
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Cites
Non-adiabatic crossing of energy levels
Zener, C. (1932) · Proceedings of the Royal Society of London Series A Containing Papers of a Mathematical and Physical Character · doi:10.1098/rspa.1932.0165 · Cited by 4,572
The First Step in Vision: Femtosecond Isomerization of Rhodopsin
Schoenlein, R. W., Peteanu, L. A., Mathies, R. A., & Shank, C. V. (1991) · Science · doi:10.1126/science.1925597 · Cited by 892
Cited by
Conformational Dynamics of Photoexcited Conjugated Molecules
Tretiak, S., Saxena, A., Martin, R. L., & Bishop, A. R. (2002) · Physical Review Letters · doi:10.1103/physrevlett.89.097402 · Cited by 371
Coherent Control of Retinal Isomerization in Bacteriorhodopsin
Prokhorenko, V. I., Nagy, A. M., Waschuk, S. A., Brown, L. S., Birge, R. R., & Miller, R. J. D. (2006) · Science · doi:10.1126/science.1130747 · Cited by 371
Metadata
- Authors
- Gai, F., Hasson, K. C., McDonald, J. C., & Anfinrud, P. A.
- Venue
- Science
- Published
- 1998-03-20
- Volume
- 279
- Issue
- 5358
- Pages
- 1886-1891
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059824119
- Cited by
- 279
- References
- 2
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gai, F., Hasson, K. C., McDonald, J. C., & Anfinrud, P. A. (1998). Chemical Dynamics in Proteins: The Photoisomerization of Retinal in Bacteriorhodopsin. Science. https://doi.org/10.1126/science.279.5358.1886
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