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Genomic Cis-Regulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene
Abstract
The genomic regulatory network that controls gene expression ultimately determines form and function in each species. The operational nature of the regulatory programming specified in cis-regulatory DNA sequence was determined from a detailed functional analysis of a sea urchin control element that directs the expression of a gene in the endoderm during development. Spatial expression and repression, and the changing rate of transcription of this gene, are mediated by a complex and extended cis-regulatory system. The system may be typical of developmental cis-regulatory apparatus. All of its activities are integrated in the proximal element, which contains seven target sites for DNA binding proteins. A quantitative computational model of this regulatory element was constructed that explicitly reveals the logical interrelations hard-wired into the DNA.
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Cited by
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Ideker, T., Galitski, T., & Hood, L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.343 · Cited by 1,664
A genomic regulatory network for development
Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C.-H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., et al. (2002) · Science · doi:10.1126/science.1069883 · Cited by 1,567
Self-citationEver-Changing Landscapes: Transcriptional Enhancers in Development and Evolution
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Metadata
- Authors
- Yuh, C.-H., Bolouri, H., & Davidson, E. H.
- Venue
- Science
- Published
- 1998-03-20
- Volume
- 279
- Issue
- 5358
- Pages
- 1896-1902
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2153800196
- Cited by
- 679
- References
- 0
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yuh, C.-H., Bolouri, H., & Davidson, E. H. (1998). Genomic Cis-Regulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene. Science. https://doi.org/10.1126/science.279.5358.1896
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