The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels
Abstract
Toxins from scorpion venom interact with potassium channels. Resin-attached, mutant K + channels from Streptomyces lividans were used to screen venom from Leiurus quinquestriatus hebraeus , and the toxins that interacted with the channel were rapidly identified by mass spectrometry. One of the toxins, agitoxin2, was further studied by mutagenesis and radioligand binding. The results show that a prokaryotic K + channel has the same pore structure as eukaryotic K + channels. This structural conservation, through application of techniques presented here, offers a new approach for K + channel pharmacology.
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Cites
Jones, T. A., Zou, J. Y., Cowan, S. W., & Kjeldgaard, M. (1991) · Acta Crystallographica Section A Foundations of Crystallography · doi:10.1107/s0108767390010224 · Cited by 12,648
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity
Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., & MacKinnon, R. (1998) · Science · doi:10.1126/science.280.5360.69 · Cited by 6,807
Self-citationNicholls, A., Sharp, K. A., & Honig, B. (1991) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340110407 · Cited by 5,240
Determination of the subunit stoichiometry of a voltage-activated potassium channel
MacKinnon, R. (1991) · Nature · doi:10.1038/350232a0 · Cited by 927
Self-citationContribution of the S4 Segment to Gating Charge in the Shaker K+ Channel
Aggarwal, S. K., & MacKinnon, R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80143-9 · Cited by 681
Self-citationInfluence of Matrix Solution Conditions on the MALDI-MS Analysis of Peptides and Proteins
Cohen, S. L., & Chait, B. T. (1996) · Analytical Chemistry · doi:10.1021/ac9507956 · Cited by 547
Self-citationRevealing the Architecture of a K + Channel Pore Through Mutant Cycles with a Peptide Inhibitor
Hidalgo, P., & MacKinnon, R. (1995) · Science · doi:10.1126/science.7716527 · Cited by 438
Self-citationThe charybdotoxin family of K+ channel-blocking peptides
Miller, C. (1995) · Neuron · doi:10.1016/0896-6273(95)90057-8 · Cited by 347
Garcia, M. L., Garcia-Calvo, M., Hidalgo, P., Lee, A., & MacKinnon, R. (1994) · Biochemistry · doi:10.1021/bi00188a012 · Cited by 269
Self-citationInteraction of charybdotoxin with permeant ions inside the pore of a K+ channel
Park, C.-S., & Miller, C. (1992) · Neuron · doi:10.1016/0896-6273(92)90169-e · Cited by 182
Cited by
Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy
Cha, A., Snyder, G. E., Selvin, P. R., & Bezanilla, F. (1999) · Nature · doi:10.1038/45552 · Cited by 473
Protein Design: From the Aspect of Water Solubility and Stability
Qing, R., Hao, S., Smorodina, E., Jin, D., Zalevsky, A., & Zhang, S. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00757 · Cited by 312
Effects of membrane lipids on ion channel structure and function
Tillman, T. S., & Cascio, M. (2003) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:38:2:161 · Cited by 265
ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide
Kalman, K., Pennington, M. W., Lanigan, M. D., Nguyen, A., Rauer, H., Mahnir, V., Paschetto, K., Kem, W. R., Grissmer, S., Gutman, G. A., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32697 · Cited by 256
On the structure and thermodynamics of solvated monoatomic ions using a hybrid solvation model
Topol, I. A., Tawa, G. J., Burt, S. K., & Rashin, A. A. (1999) · The Journal of Chemical Physics · doi:10.1063/1.480486 · Cited by 128
Metadata
- Authors
- MacKinnon, R., Cohen, S. L., Kuo, A., Lee, A., & Chait, B. T.
- Venue
- Science
- Published
- 1998-04-03
- Volume
- 280
- Issue
- 5360
- Pages
- 106-109
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037539407
- Cited by
- 408
- References
- 13
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- MacKinnon, R., Cohen, S. L., Kuo, A., Lee, A., & Chait, B. T. (1998). Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels. Science. https://doi.org/10.1126/science.280.5360.106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
