The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches
Abstract
Cryptopatches (CPs) are part of the murine intestinal immune compartment. Cells isolated from CPs of the small intestine that were c-kit positive (c-kit + ) but lineage markers negative (Lin − ) gave rise to T cell receptor (TCR) αβ and TCR γδ intestinal intraepithelial T cells after in vivo transfer or tissue engraftment into severe combined immunodeficient mice. In contrast, cells from Peyer's patches and mesenteric lymph nodes, which belong in the same intestinal immune compartment but lack c-kit + Lin − cells, failed to do so. These findings and results of electron microscopic analysis provide evidence of a local intestinal T cell precursor that develops in the CPs.
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Cites
Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin
Cepek, K. L., Shaw, S. K., Parker, C. M., Russell, G. J., Morrow, J. S., Rimm, D. L., & Brenner, M. B. (1994) · Nature · doi:10.1038/372190a0 · Cited by 1,178
Cited by
Probiotics: effects on immunity
Isolauri, E., Sütas, Y., Kankaanpää, P., Arvilommi, H., & Salminen, S. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.444s · Cited by 1,019
The light and dark sides of intestinal intraepithelial lymphocytes
Cheroutre, H., Lambolez, F., & Mucida, D. (2011) · Nature Reviews Immunology · doi:10.1038/nri3007 · Cited by 693
Rombout, J. H. W. M., Abelli, L., Picchietti, S., Scapigliati, G., & Kiron, V. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2010.09.001 · Cited by 608
Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes
Van Kaer, L., & Olivares-Villagómez, D. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701704 · Cited by 101
Interleukin-15 and the regulation of lymphoid homeostasis
Lodolce, J., Burkett, P., Koka, R., Boone, D., Chien, M., Chan, F., Madonia, M., Chai, S., & Ma, A. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00211-0 · Cited by 71
Metadata
- Authors
- Saito, H., Kanamori, Y., Takemori, T., Nariuchi, H., Kubota, E., Takahashi-Iwanaga, H., Iwanaga, T., & Ishikawa, H.
- Venue
- Science
- Published
- 1998-04-10
- Volume
- 280
- Issue
- 5361
- Pages
- 275-278
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034391780
- Cited by
- 291
- References
- 1
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saito, H., Kanamori, Y., Takemori, T., Nariuchi, H., Kubota, E., Takahashi-Iwanaga, H., Iwanaga, T., & Ishikawa, H. (1998). Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches. Science. https://doi.org/10.1126/science.280.5361.275
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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