Interleukin-15 and the regulation of lymphoid homeostasis

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Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

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Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

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Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

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IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

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Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

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Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

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Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

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Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

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Visualizing the generation of memory CD4 T cells in the whole body

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Utilization of the beta and gamma chains of the IL‐2 receptor by the novel cytokine IL‐15.

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Interleukin 15: biology and relevance to human disease

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IL-7 is critical for homeostatic proliferation and survival of naïve T cells

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Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

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Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

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Control of Homeostasis of CD8 + Memory T Cells by Opposing Cytokines

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Selecting and maintaining a diverse T-cell repertoire

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The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

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Selecting and maintaining a diverse T-cell repertoire

Goldrath, A. W., & Bevan, M. J. (1999) · Nature · doi:10.1038/35005508 · Cited by 714 · see citing works

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

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Identification and cloning of a novel IL‐15 binding protein that is structurally related to the alpha chain of the IL‐2 receptor.

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Cytokine-driven Proliferation and Differentiation of Human Naive, Central Memory, and Effector Memory CD4+ T Cells

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Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

Cho, B. K., Rao, V. P., Ge, Q., Eisen, H. N., & Chen, J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.549 · Cited by 509 · see citing works

Immune Responses in Interleukin-2-Deficient Mice

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Cutting Edge: Naive T Cells Masquerading as Memory Cells

Murali‐Krishna, K., & Ahmed, R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1733 · Cited by 462 · see citing works

IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation

Mattei, F., Schiavoni, G., Belardelli, F., & Tough, D. F. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1179 · Cited by 460 · see citing works

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

Tagaya, Y., Bamford, R. N., DeFilippis, A. P., & Waldmann, T. A. (1996) · Immunity · doi:10.1016/s1074-7613(00)80246-0 · Cited by 440 · see citing works

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

Bamford, R. N., Grant, A. J., Burton, J. D., Peters, C., Kurys, G., Goldman, C. K., Brennan, J., Roessler, E., & Waldmann, T. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4940 · Cited by 411 · see citing works

Cytokine-induced survival of activated T cells in vitro and in vivo

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Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells

Fehniger, T. A., Suzuki, K., Ponnappan, A., VanDeusen, J. B., Cooper, M. A., Florea, S. M., Freud, A. G., Robinson, M. L., Durbin, J. E., & Caligiuri, M. A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.2.219 · Cited by 373 · see citing works

Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

Anderson, D. M., Kumaki, S., Ahdieh, M., Bertles, J. S., Tometsko, M. E., Loomis, A., Giri, J. G., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.29862 · Cited by 372 · see citing works

Identification of committed NK cell progenitors in adult murine bone marrow

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Type I Interferon-mediated Stimulation of T Cells by CpG DNA

Sun, S., Zhang, X. M., Tough, D. F., & Sprent, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2335 · Cited by 360 · see citing works

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

Suzuki, H., Duncan, G. S., Takimoto, H., & Mak, T. W. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.499 · Cited by 351 · see citing works

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

Tough, D. F., Sun, S., & Sprent, J. D. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.12.2089 · Cited by 347 · see citing works

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

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Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

Kieper, W. C., & Jameson, S. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13306 · Cited by 341 · see citing works

Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches

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Homeostatic T Cell Proliferation

Surh, C. D., & Sprent, J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.f9 · Cited by 277 · see citing works

Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

Bamford, R. N., Battiata, A. P., Burton, J. D., Sharma, H. S., & Waldmann, T. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2897 · Cited by 222 · see citing works

Human Monocytes Constitutively Express Membrane-Bound, Biologically Active, and Interferon-γ–Upregulated Interleukin-15

Musso, T., Calosso, L., Zucca, M., Millesimo, M., Ravarino, D., Giovarelli, M., Malavasi, F., Ponzi, A. N., Paus, R., & Bulfone‐Paus, S. (1999) · Blood · doi:10.1182/blood.v93.10.3531.410k32_3531_3539 · Cited by 218 · see citing works

Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

Tagaya, Y., Kurys, G., Thies, T. A., Losi, J. M., Azimi, N., Hanover, J. A., Bamford, R. N., & Waldmann, T. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14444 · Cited by 210 · see citing works

Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation

Yang, J., Murphy, T. L., Ouyang, W., & MURPHY, K. M. M. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199902)29:02 · Cited by 195 · see citing works

The 5′ Untranslated Region, Signal Peptide, and the Coding Sequence of the Carboxyl Terminus of IL-15 Participate in Its Multifaceted Translational Control

Bamford, R. N., DeFilippis, A. P., Azimi, N., Kurys, G., & Waldmann, T. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.9.4418 · Cited by 189 · see citing works

Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms

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Critical role of IL-15–IL-15R for antigen-presenting cell functions in the innate immune response

Ohteki, T., Suzue, K., Maki, C., Ota, T., & Koyasu, S. (2001) · Nature Immunology · doi:10.1038/ni729 · Cited by 176 · see citing works

T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation

Lodolce, J. P., Burkett, P. R., Boone, D. L., Chien, M., & Ma, A. I. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.8.1187 · Cited by 176 · see citing works

The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

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Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.

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Autologous Regulation of Naive T Cell Homeostasis Within the T Cell Compartment

Dummer, W., Ernst, B., LeRoy, E., Lee, D., & Surh, C. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2460 · Cited by 151 · see citing works

Differential Roles of Interleukin 15 mRNA Isoforms Generated by Alternative Splicing in Immune Responses in Vivo

Nishimura, H., Yajima, T., Naiki, Y., Tsunobuchi, H., Umemura, M., Itano, K., Matsuguchi, T., Suzuki, M., Ohashi, P. S., & Yoshikai, Y. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.157 · Cited by 147 · see citing works

IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells

Puzanov, I. J., Bennett, M. V. L., & Kumar, V. B. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.10.4282 · Cited by 145 · see citing works

Identification of a novel receptor/signal transduction pathway for IL‐15/T in mast cells.

Tagaya, Y., Burton, J. D., Miyamoto, Y., & Waldmann, T. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00873.x · Cited by 141 · see citing works

Erratum To: Identification of a novel receptor/signal transduction pathway for IL‐15/T in mast cells

Tagaya, Y., Burton, J. D., Miyamoto, Y., & Waldmann, T. A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.6 · Cited by 130 · see citing works

IL-12 Enhances CD8 T Cell Homeostatic Expansion

Kieper, W. C., Prlic, M., Schmidt, C. S., Mescher, M. F., & Jameson, S. C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5515 · Cited by 119 · see citing works

Homeostatic Expansion Occurs Independently of Costimulatory Signals

Prlic, M., Blazar, B. R., Khoruts, A., Zell, T., & Jameson, S. C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5664 · Cited by 118 · see citing works

The Pleiotropic Functions of Interleukin 15

Ma, A., Boone, D. L., & Lodolce, J. P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.5.753 · Cited by 102 · see citing works

Lipopolysaccharide-Stimulated or Granulocyte-Macrophage Colony-Stimulating Factor-Stimulated Monocytes Rapidly Express Biologically Active IL-15 on Their Cell Surface Independent of New Protein Synthesis

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Cytokines: Shared receptors, distinct functions

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Viral Activation of Interleukin-15 (IL-15): Characterization of a Virus-Inducible Element in the IL-15 Promoter Region

Azimi, N., Tagaya, Y., Mariner, J. M., & Waldmann, T. A. (2000) · Journal of Virology · doi:10.1128/jvi.74.16.7338-7348.2000 · Cited by 65 · see citing works

Cytokines: IL-21 joins the γc-dependent network?

Vosshenrich, C. A. J., & Santo, J. P. D. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00087-2 · Cited by 60 · see citing works

IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development.

Porter, B. O., & Malek, T. R. (1999) · PubMed · Cited by 46 · see citing works

IL-2Rβ/IL-7Rα Doubly Deficient Mice Recapitulate the Thymic and Intraepithelial Lymphocyte (IEL) Developmental Defects of γc−/− Mice: Roles for Both IL-2 and IL-15 in CD8αα IEL Development

Porter, B. O., & Malek, T. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.5906 · Cited by 41 · see citing works

Differential Effects of IL-2 and IL-15 on Expression of IL-2 Receptor α

Alileche, A., Goldman, C. K., & Waldmann, T. A. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5332 · Cited by 18 · see citing works

Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1+ T cells

Tucker, S. N., Jessup, H. K., Fujii, H., & Wilson, C. B. (2002) · Blood · doi:10.1182/blood.v99.2.513 · Cited by 12 · see citing works

T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells

Townsend, M. J., Weinmann, A. S., Matsuda, J. L., Salomon, R., Farnham, P., Biron, C. A., Gapin, L., & Glimcher, L. H. (2004) · Immunity · doi:10.1016/s1074-7613(04)00076-7 · Cited by 722 · see citing works

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471 · see citing works

Host-reactive CD8+ memory stem cells in graft-versus-host disease

Zhang, Y., Joe, G., Hexner, E., Zhu, J., & Emerson, S. G. (2005) · Nature Medicine · doi:10.1038/nm1326 · Cited by 369 · see citing works

Cytokines and immunodeficiency diseases: critical roles of the γc‐dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

Kovanen, P., & Leonard, W. J. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00203.x · Cited by 409 · see citing works

Cutting Edge: Transpresentation of IL-15 by Bone Marrow-Derived Cells Necessitates Expression of IL-15 and IL-15Rα by the Same Cells

Sandau, M. M., Schluns, K. S., Lefrançois, L., & Jameson, S. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.11.6537 · Cited by 175 · see citing works

Shared Alterations in NK Cell Frequency, Phenotype, and Function in Chronic Human Immunodeficiency Virus and Hepatitis C Virus Infections

Meier, U., Owen, R. E., Taylor, E., Worth, A. T., Naoumov, N. V., Willberg, C. B., Tang, K. H., Newton, P., Pellegrino, P., Williams, I. G., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.19.12365-12374.2005 · Cited by 174 · see citing works

Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer

Waldmann, T. A., Miljković, M. D., & Conlon, K. C. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20191062 · Cited by 129 · see citing works

Natural killer cells: Primary target for hepatitis C virus immune evasion strategies?

Golden‐Mason, L., & Rosen, H. R. (2006) · Liver Transplantation · doi:10.1002/lt.20708 · Cited by 106 · see citing works

Initial Antigen Encounter Programs CD8+ T Cells Competent to Develop into Memory Cells That Are Activated in an Antigen-Free, IL-7- and IL-15-Rich Environment

Carrió, R., Bathe, O. F., & Malek, T. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7315 · Cited by 102 · see citing works

IL-15 Superagonist–Mediated Immunotoxicity: Role of NK Cells and IFN-γ

Guo, Y., Luan, L., Rabacal, W., Bohannon, J. K., Fensterheim, B. A., Hernandez, A., & Sherwood, E. R. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500300 · Cited by 103 · see citing works

Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15

Wysocka, M., Benoit, B. M., Newton, S. B., Azzoni, L., Montaner, L. J., & Rook, A. H. (2004) · Blood · doi:10.1182/blood-2004-03-1190 · Cited by 97 · see citing works

Membrane-bound and soluble IL-15/IL-15Rα complexes display differential signaling and functions on human hematopoietic progenitors

Giron‐Michel, J., Giuliani, M., Fogli, M., Brouty‐Boyé, D., Ferrini, S., Baychelier, F., Eid, P., Bousse‐Kerdilès, M. L., Duralı, D., Biassoni, R., et al. (2005) · Blood · doi:10.1182/blood-2005-01-0064 · Cited by 95 · see citing works

Functions of IL-15 in anti-viral immunity: Multiplicity and variety

Verbist, K., & Klonowski, K. D. (2012) · Cytokine · doi:10.1016/j.cyto.2012.05.020 · Cited by 92 · see citing works

Survival adjustment of mature dendritic cells by IL-15

Dubois, S. P., Waldmann, T. A., & Müller, J. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503360102 · Cited by 90 · see citing works

Antibodies as therapeutic agents: vive la renaissance!

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Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm

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