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Control of Alternative Splicing of Potassium Channels by Stress Hormones
Abstract
Many molecular mechanisms for neural adaptation to stress remain unknown. Expression of alternative splice variants of Slo, a gene encoding calcium- and voltage-activated potassium channels, was measured in rat adrenal chromaffin tissue from normal and hypophysectomized animals. Hypophysectomy triggered an abrupt decrease in the proportion of Slo transcripts containing a “STREX” exon. The decrease was prevented by adrenocorticotropic hormone injections. In Xenopus oocytes, STREX variants produced channels with functional properties associated with enhanced repetitive firing. Thus, the hormonal stress axis is likely to control the excitable properties of epinephrine-secreting cells by regulating alternative splicing of Slo messenger RNA.
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Cited by
Molecular Diversity of K+ Channels
COETZEE, W. A., AMARILLO, Y., CHIU, J., CHOW, A., LAU, D., McCORMACK, T., MORENA, H., NADAL, M. S., OZAITA, A., POUNTNEY, D., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11293.x · Cited by 1,095
Dynamics and Consequences of Potassium Shifts in Skeletal Muscle and Heart During Exercise
Sejersted, O. M., & Sjøgaard, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1411 · Cited by 490
Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges
Lovci, M. T., Ghanem, D., Marr, H., Arnold, J., Gee, S., Parra, M., Liang, T. Y., Stark, T. J., Gehman, L. T., Hoon, S., et al. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2699 · Cited by 385
MECHANISMS OF HAIR CELL TUNING
Fettiplace, R., & Fuchs, P. A. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.809 · Cited by 417
Neuronal regulation of alternative pre-mRNA splicing
Li, Q., Lee, J.-A., & Black, D. L. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2237 · Cited by 376
Metadata
- Authors
- Xie, J., & McCobb, D. P.
- Venue
- Science
- Published
- 1998-04-17
- Volume
- 280
- Issue
- 5362
- Pages
- 443-446
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089157424
- Cited by
- 296
- References
- 0
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xie, J., & McCobb, D. P. (1998). Control of Alternative Splicing of Potassium Channels by Stress Hormones. Science. https://doi.org/10.1126/science.280.5362.443
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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