Molecular Diversity of K+ Channels
Abstract
ABSTRACT: K+ channel principal subunits are by far the largest and most diverse of the ion channels. This diversity originates partly from the large number of genes coding for K+ channel principal subunits, but also from other processes such as alternative splicing, generating multiple mRNA transcripts from a single gene, heteromeric assembly of different principal subunits, as well as possible RNA editing and posttranslational modifications. In this chapter, we attempt to give an overview (mostly in tabular format) of the different genes coding for K+ channel principal and accessory subunits and their genealogical relationships. We discuss the possible correlation of different principal subunits with native K+ channels, the biophysical and pharmacological properties of channels formed when principal subunits are expressed in heterologous expression systems, and their patterns of tissue expression. In addition, we devote a section to describing how diversity of K+ channels can be conferred by heteromultimer formation, accessory subunits, alternative splicing, RNA editing and posttranslational modifications. We trust that this collection of facts will be of use to those attempting to compare the properties of new subunits to the properties of others already known or to those interested in a comparison between native channels and cloned candidates.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Kv3 channels have a 10-50 mV higher activation threshold than any other known mammalian voltage-gated K+ channels.
“The Kv3 channels have a 10-50 mV higher activation threshold than any other known mammalian voltage-gated K+ channels (Coetzee et al., 1999).”
From Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms (2021) · cites this paper as Coetzee et al., 1999
Cites
Calcium-activated potassium channels
Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80056-1 · Cited by 954 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
Rudy, B., & McBain, C. J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01892-0 · Cited by 781 · see citing works
Self-citationErisir, A., Lau, D., Rudy, B., & Leonard, C. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.5.2476 · Cited by 458 · see citing works
Self-citationBellingham, M. C. (2011) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00116.x · Cited by 388 · see citing works
Contributions of Kv3 Channels to Neuronal Excitability
RUDY, B., CHOW, A., LAU, D., AMARILLO, Y., OZAITA, A., SAGANICH, M., MORENO, H., NADAL, M. S., HERNANDEZ‐PINEDA, R., HERNANDEZ‐CRUZ, A., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11295.x · Cited by 305 · see citing works
Self-citationMetabolic cost as a unifying principle governing neuronal biophysics.
Hasenstaub, A., Otte, S., Callaway, E., & Sejnowski, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914886107 · Cited by 246 · see citing works
Toledo-Rodriguez, M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh092 · Cited by 241 · see citing works
Azad, S. C., Eder, M., Marsicano, G., Lutz, B., Zieglgänsberger, W., & Rammes, G. (2003) · Learning & Memory · doi:10.1101/lm.53303 · Cited by 220 · see citing works
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy
Li, K.-X., Lu, Y.-M., Xu, Z.-H., Zhang, J., Zhu, J.-M., Zhang, J.-M., Cao, S.-X., Chen, X.-J., Chen, Z., Luo, J.-H., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3006 · Cited by 173 · see citing works
Phylogeny of ion channels: clues to structure and function
Anderson, P. A. V., & Greenberg, R. M. (2001) · Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(01)00376-1 · Cited by 171 · see citing works
Lahiri, A. K., & Bevan, M. D. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.028 · Cited by 133 · see citing works
Shi, Y., Andhey, P. S., Ising, C., Wang, K., Snipes, L. L., Boyer, K., Lawson, S., Yamada, K., Qin, W., Manis, M., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.034 · Cited by 135 · see citing works
Lien, C., Martina, M., Schultz, J. H., Ehmke, H., & Jonas, P. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013066 · Cited by 124 · see citing works
Yanagi, M., Joho, R. H., Southcott, S. A., Shukla, A. A., Ghose, S., & Tamminga, C. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.49 · Cited by 102 · see citing works
Mislocalization of K<sub>ir</sub> channels in malignant glia
Olsen, M. L., & Sontheimer, H. (2004) · Glia · doi:10.1002/glia.10346 · Cited by 97 · see citing works
Transcriptomic correlates of neuron electrophysiological diversity
Tripathy, S. J., Toker, L., Li, B., Crichlow, C.-L., Tebaykin, D., Mancarci, B. O., & Pavlidis, P. (2017) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005814 · Cited by 69 · see citing works
Kv4.3-Mediated A-Type K<sup>+</sup>Currents Underlie Rhythmic Activity in Hippocampal Interneurons
Bourdeau, M. L., Morin, F., Laurent, C. E., Azzi, M., & Lacaille, J.-C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3208-06.2007 · Cited by 75 · see citing works
Synapse-Level Determination of Action Potential Duration by K + Channel Clustering in Axons
Rowan, M. J. M., DelCanto, G., Yu, J. J., Kamasawa, N., & Christie, J. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.035 · Cited by 66 · see citing works
Tansey, E. P., Chow, A., Rudy, B., & McBain, C. J. (2002) · Hippocampus · doi:10.1002/hipo.1104 · Cited by 74 · see citing works
Self-citationTransduction and encoding sensory information by skin mechanoreceptors
Hao, J., Bonnet, C., Amsalem, M., Ruel, J., & Delmas, P. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1651-7 · Cited by 71 · see citing works
Azad, S. C., Kurz, J., Marsicano, G., Lutz, B., Zieglgänsberger, W., & Rammes, G. (2008) · Learning & Memory · doi:10.1101/lm.741908 · Cited by 68 · see citing works
Perry, S., Gezelius, H., Larhammar, M., Hilscher, M. M., Lamotte d'Incamps, B., Leao, K. E., & Kullander, K. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12852 · Cited by 32 · see citing works
Review: Potassium channels in the human fetoplacental vasculature
Wareing, M., & Greenwood, S. L. (2011) · Placenta · doi:10.1016/j.placenta.2010.12.022 · Cited by 20 · see citing works
- Authors
- COETZEE, W. A., AMARILLO, Y., CHIU, J., CHOW, A., LAU, D., McCORMACK, T., MORENA, H., NADAL, M. S., OZAITA, A., POUNTNEY, D., SAGANICH, M., DE MIERA, E. V., & RUDY, B.
- Affiliations
- NYU Langone Health (US)
- New York University (US)
- Corresponding author
- COETZEE, WILLIAM A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1999-04
- Volume
- 868
- Issue
- 1
- Pages
- 233-255
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2099587101
- Cited by
- 1,095
- References
- 1
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 19 · 2023: 15 · 2022: 20 · 2021: 31 · 2020: 29 · 2019: 27 · 2018: 25 · 2017: 22 · 2016: 30 · 2015: 35 · 2014: 50 · 2013: 44 · 2012: 41
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- potassium channels, potassium channel subunits, molecular diversity, alternative splicing, auxiliary subunits, RNA editing, post-translational modification, genealogy, tissue expression, channel pharmacology, heterologous expression
- MeSH terms
- Animals, Cloning, Molecular, Gene Expression Regulation, Humans, Phylogeny, Protein Conformation, Protein Processing, Post-Translational, RNA, Messenger, Xenopus, Potassium Channels, Ion Channel Gating, RNA Editing, Alternative Splicing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
