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Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts
Abstract
An efficient system for genetic modification and large-scale cloning of cattle is of importance for agriculture, biotechnology, and human medicine. Here, actively dividing fetal fibroblasts were genetically modified with a marker gene, a clonal line was selected, and the cells were fused to enucleated mature oocytes. Out of 28 embryos transferred to 11 recipient cows, three healthy, identical, transgenic calves were generated. Furthermore, the life-span of near senescent fibroblasts could be extended by nuclear transfer, as indicated by population doublings in fibroblast lines derived from a 40-day-old fetal clone. With the ability to extend the life-span of these primary cultured cells, this system would be useful for inducing complex genetic modifications in cattle.
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Xia, Y., Rogers, J. A., Paul, K. E., & Whitesides, G. M. (1999) · Chemical Reviews · doi:10.1021/cr980002q · Cited by 1,538
Cloned pigs produced by nuclear transfer from adult somatic cells
Polejaeva, I. A., Chen, S.-H., Vaught, T. D., Page, R. L., Mullins, J., Ball, S., Dai, Y., Boone, J., Walker, S., Ayares, D. L., et al. (2000) · Nature · doi:10.1038/35024082 · Cited by 1,254
Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells
Lanza, R. P., Cibelli, J. B., Blackwell, C., Cristofalo, V. J., Francis, M. K., Baerlocher, G. M., Mak, J., Schertzer, M., Chavez, E. A., Sawyer, N., et al. (2000) · Science · doi:10.1126/science.288.5466.665 · Cited by 466
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Metadata
- Authors
- Cibelli, J. B., Stice, S. L., Golueke, P. J., Kane, J. J., Jerry, J., Blackwell, C., Ponce de León, F. A., & Robl, J. M.
- Venue
- Science
- Published
- 1998-05-22
- Volume
- 280
- Issue
- 5367
- Pages
- 1256-1258
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2003701368
- Cited by
- 1,396
- References
- 0
- FWCI
- 53.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts. https://app.cochat.ai/papers/10.1126/science.280.5367.1256
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- Cibelli, J. B., Stice, S. L., Golueke, P. J., Kane, J. J., Jerry, J., Blackwell, C., Ponce de León, F. A., & Robl, J. M. (1998). Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts. Science. https://doi.org/10.1126/science.280.5367.1256
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