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Helical Superstructures from Charged Poly(styrene)-Poly(isocyanodipeptide) Block Copolymers
Open accessAbstract
Amphiphilic block copolymers containing a poly(styrene) tail and a charged helical poly(isocyanide) headgroup derived from isocyano- l -alanine- l -alanine and isocyano- l -alanine- l -histidine were prepared. Analogous to low–molecular mass surfactants, these block copolymers self-assembled in aqueous systems to form micelles, vesicles, and bilayer aggregates. The morphology of these aggregates can be controlled by variation of the length of the poly(isocyanide) block, the pH, and the anion-headgroup interactions. The chirality of the macromolecules results in the formation of helical superstructures that have a helical sense opposite to that of the constituent block copolymers. The great variety of morphologies displayed by these block copolymers and the fact that they are easily accessible from poly(styrene) and different types of peptides open new opportunities for applications in the fields of life and materials sciences.
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Citations
Cited by
Yashima, E., Ousaka, N., Taura, D., Shimomura, K., Ikai, T., & Maeda, K. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00354 · Cited by 2,004
Synthetic Helical Polymers: Conformation and Function
Nakano, T., & Okamoto, Y. (2001) · Chemical Reviews · doi:10.1021/cr0000978 · Cited by 1,375
Discher, D. E., & Ahmed, F. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095838 · Cited by 844
Mastering molecular matter. Supramolecular architectures by hierarchical self-assembly
Elemans, J. A. A. W., Rowan, A. E., & Nolte, R. J. M. (2003) · J. Mater. Chem. · doi:10.1039/b304972h · Cited by 473
Self-citationCoarse grain models and the computer simulation of soft materials
Nielsen, S. O., Lopez, C. F., Srinivas, G., & Klein, M. L. (2004) · Journal of Physics: Condensed Matter · doi:10.1088/0953-8984/16/15/r03 · Cited by 423
Metadata
- Authors
- Cornelissen, J. J. L. M., Fischer, M., Sommerdijk, N. A. J. M., & Nolte, R. J. M.
- Venue
- Science
- Published
- 1998-05-29
- Volume
- 280
- Issue
- 5368
- Pages
- 1427-1430
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083681888
- Cited by
- 611
- References
- 0
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Cornelissen, J. J. L. M., Fischer, M., Sommerdijk, N. A. J. M., & Nolte, R. J. M. (1998). Helical Superstructures from Charged Poly(styrene)-Poly(isocyanodipeptide) Block Copolymers. Science. https://doi.org/10.1126/science.280.5368.1427
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