The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency
Abstract
In humans, interferon γ (IFN-γ) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-γ concentrations were found to be secreted by activated natural killer and T cells. Thus, IL-12–dependent IFN-γ secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12–independent IFN-γ secretion.
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Citations
Cites
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Cited by
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252
Molecular Mechanisms RegulatinG Th1 Immune Responses
Szabo, S. J., Sullivan, B. M., Peng, S. L., & Glimcher, L. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140942 · Cited by 1,019
Genetic Dissection of Immunity to Mycobacteria: The Human Model
Casanova, J.-L., & Abel, L. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.125851 · Cited by 991
Self-citationTeng, M. W. L., Bowman, E. P., McElwee, J. J., Smyth, M. J., Casanova, J.-L., Cooper, A. M., & Cua, D. J. (2015) · Nature Medicine · doi:10.1038/nm.3895 · Cited by 873
Self-citationMedium- and Large-Vessel Vasculitis
Weyand, C. M., & Goronzy, J. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022694 · Cited by 788
Metadata
- Authors
- Altare, F., Durandy, A., Lammas, D., Emile, J.-F., Lamhamedi, S., Le Deist, F., Drysdale, P., Jouanguy, E., Döffinger, R., Bernaudin, F., Jeppsson, O., Gollob, J. A., Meinl, E., Segal, A. W., Fischer, A., Kumararatne, D., & Casanova, J.-L.
- Venue
- Science
- Published
- 1998-05-29
- Volume
- 280
- Issue
- 5368
- Pages
- 1432-1435
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2135254713
- Cited by
- 845
- References
- 1
- FWCI
- 24.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Altare, F., Durandy, A., Lammas, D., Emile, J.-F., Lamhamedi, S., Le Deist, F., Drysdale, P., Jouanguy, E., Döffinger, R., Bernaudin, F., Jeppsson, O., Gollob, J. A., Meinl, E., Segal, A. W., Fischer, A., Kumararatne, D., & Casanova, J.-L. (1998). Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency. Science. https://doi.org/10.1126/science.280.5368.1432
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
