The DOI matches its Crossref record.
Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor
Abstract
A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC. Incubation of HSV-1 with a secreted form of HveC inhibited subsequent infection of a variety of cell lines, suggesting that HveC interacts directly with the virus. Poliovirus receptor (Pvr) itself mediated entry of PRV and BHV-1 but not of the HSV strains tested. HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system.
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Citations
Cited by
Virus entry: molecular mechanisms and biomedical applications
Dimitrov, D. S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro817 · Cited by 701
Spear, P. G., & Longnecker, R. (2003) · Journal of Virology · doi:10.1128/jvi.77.19.10179-10185.2003 · Cited by 590
Self-citationWarner, M. S., Geraghty, R. J., Martinez, W. M., Montgomery, R. I., Whitbeck, J. C., Xu, R., Eisenberg, R. J., Cohen, G. H., & Spear, P. G. (1998) · Virology · doi:10.1006/viro.1998.9218 · Cited by 494
Self-citationHuman fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2
Qing, K., Mah, C., Hansen, J., Zhou, S., Dwarki, V., & Srivastava, A. (1999) · Nature Medicine · doi:10.1038/4758 · Cited by 443
Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor HveA
Carfı́, A., Willis, S. H., Whitbeck, J. C., Krummenacher, C., Cohen, G. H., Eisenberg, R. J., & Wiley, D. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00298-2 · Cited by 391
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Metadata
- Authors
- Geraghty, R. J., Krummenacher, C., Cohen, G. H., Eisenberg, R. J., & Spear, P. G.
- Venue
- Science
- Published
- 1998-06-05
- Volume
- 280
- Issue
- 5369
- Pages
- 1618-1620
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997221411
- Cited by
- 909
- References
- 0
- FWCI
- 39.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Geraghty, R. J., Krummenacher, C., Cohen, G. H., Eisenberg, R. J., & Spear, P. G. (1998). Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor. Science. https://doi.org/10.1126/science.280.5369.1618
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
