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Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node
Abstract
Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell–rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.
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Citations
Cited by
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
Wei, S. C., Duffy, C. R., & Allison, J. P. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0367 · Cited by 3,088
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
Breitfeld, D., Ohl, L., Kremmer, E., Ellwart, J., Sallusto, F., Lipp, M., & Förster, R. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1545 · Cited by 1,464
Vinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141
Metadata
- Authors
- Garside, P., Ingulli, E., Merica, R. R., Johnson, J. G., Noelle, R. J., & Jenkins, M. K.
- Venue
- Science
- Published
- 1998-07-03
- Volume
- 281
- Issue
- 5373
- Pages
- 96-99
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992949591
- Cited by
- 774
- References
- 0
- FWCI
- 13.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garside, P., Ingulli, E., Merica, R. R., Johnson, J. G., Noelle, R. J., & Jenkins, M. K. (1998). Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node. Science. https://doi.org/10.1126/science.281.5373.96
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
